Evidence map›Paper›PMID 35615349›Full record

ArticleFrontiers in immunology2022

Pharmacological Inhibition of MALT1 Ameliorates Autoimmune Pathogenesis and Can Be Uncoupled From Effects on Regulatory T-Cells.

Subhabrata Biswas, Aditi Chalishazar, Ynes Helou, Joanna DiSpirito, Brian DeChristopher, Devin Chatterjee, Leidy Merselis, Benjamin Vincent, John G Monroe, Dania Rabah and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. BloodBiomarkers in medicine · 2024
    Article
  8. Translational Studies Using the MALT1 Inhibitor (Journal of immunotherapy and precision oncology · 2023
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Subhabrata BiswasImmunology, Rheos Medicines, Cambridge, MA, United States.
Aditi ChalishazarImmunology, Rheos Medicines, Cambridge, MA, United States.
Ynes HelouImmunology, Rheos Medicines, Cambridge, MA, United States.
Joanna DiSpiritoImmunology, Rheos Medicines, Cambridge, MA, United States.
Brian DeChristopherDrug Discovery, Rheos Medicines, Cambridge, MA, United States.
Devin ChatterjeeImmunology, Rheos Medicines, Cambridge, MA, United States.
Leidy MerselisImmunology, Rheos Medicines, Cambridge, MA, United States.
Benjamin VincentDrug Discovery, Rheos Medicines, Cambridge, MA, United States.
John G MonroeResearch and Development, Rheos Medicines, Cambridge, MA, United States.
Dania RabahResearch and Development, Rheos Medicines, Cambridge, MA, United States.
Andrew J LongImmunology, Rheos Medicines, Cambridge, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MALT1 forms part of a central signaling node downstream of immunoreceptor tyrosine-based activation motif (ITAM)-containing receptors, across a broad range of immune cell subsets, and regulates NF-κB driven transcriptional responses

Indexed as

Autoimmune DiseasesMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinT-Lymphocytes, RegulatoryAnimalsCytokinesInflammationLymphocyte ActivationNF-kappa BRatsCytokinesMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinNF-kappa Bautoimmunitycollagen-induced arthritisIL-2MALT1 inhibitorregulatory T-cell

Identifiers

PMID35615349
PMCPMC9125252
OpenAlexW4229376757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.