Evidence map›Paper›PMID 35615115›Full record

ArticleNeuroscience insights2022

Harnessing Spinal Interneurons for Spinal Cord Repair.

Lyandysha V Zholudeva, Michael A Lane

Abstract readComment
In one paragraph

Article in Neuroscience insights, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Lyandysha V ZholudevaGladstone Institutes, San Francisco, CA, USA.ORCID https://orcid.org/0000-0003-4995-8466
Michael A LaneMarion Murray Spinal Cord Research Center, Philadelphia, PA, USA.

Funding

Neural transplants to promote respiratory plasticity after spinal cord injuryR01NS104291 · NINDS · DREXEL UNIVERSITY · PI LANE, MICHAEL ARON · 2018 to 2022
$1.7M
Engineering Human Interneurons for Neural RepairF32NS119348 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI ZHOLUDEVA, LYANDYSHA VIKTOROVNA · 2021 to 2022
$91k
NINDS NIH HHS F32 NS119348NINDS NIH HHS R01 NS104291
6 · The paper itself

Abstract

Interest in spinal interneurons (SpINs), their heterogeneity in the naive spinal cord and their varying responses to central nervous system injury or disease has been steadily increasing. Our recent review on this topic highlights the vast phenotypic heterogeneity of SpINs and the efforts being made to better identify and classify these neurons. As our understanding of SpIN phenotype, connectivity, and neuroplastic capacity continues to expand, new therapeutic targets are being revealed and novel treatment approaches developed to harness their potential. Here, we expand on that initial discussion and highlight how SpINs can be used to develop advanced, targeted cellular therapies and personalized medicines.

Indexed as

cellular engineeringneuroplasticityneurotraumaSpinal interneuronsstem cells

Identifiers

PMID35615115
PMCPMC9125099

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.