ArticleJournal of inflammation research2022
Association Between Depression or Anxiety and the Risk of Hepatitis B Flares: A Nationwide Population-Based Cohort Study.
Article in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Associations of depression with incident liver and spleen diseases: a retrospective cohort study.BMC public health · 2026Article
- Construction of a depression risk prediction model for hepatitis B patients based on machine learning strategy.PloS one · 2026Article
- Psychiatric symptoms and necroinflammatory activity in chronic hepatitis B: a cross-sectional study.BMC infectious diseases · 2025Article
- A culturally adapted mobile cognitive behavioral therapy for individuals with Hepatitis B on depression, anxiety and stress: A pilot randomized controlled trial.Internet interventions · 2025Article
- Review
- Trajectories of depressive symptoms and risk of chronic liver disease: evidence from CHARLS.BMC gastroenterology · 2025Article
- Decomposition and comparative analysis of differences in anxiety between urban and rural Chinese adults: a national cross-sectional study.BMC public health · 2025Article
- The relationship between dyslipidemia and chronic liver disease, with the mediating role of depressive symptoms.Frontiers in public health · 2025Article
- Is There such a Thing as Post-Viral Depression?: Implications for Precision Medicine.Biomolecules & therapeutics · 2024Review
- Does Alexithymia Predict the Psychiatric Comorbidity Among Healthy Carriers of Hepatitis B?Alpha psychiatry · 2024Article
- Article
- Causal associations between chronic viral hepatitis and psychiatric disorders: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Bidirectional Relationship between HIV/HBV Infection and Comorbid Depression and/or Anxiety: A Systematic Review on Shared Biological Mechanisms.Journal of personalized medicine · 2023Review
- Association of depressive symptoms with chronic liver disease among middle-aged and older adults in China.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Depression and anxiety have been reported to increase the risk of infectious diseases and reactivation of latent infection. We conducted a nationwide population-based retrospective cohort study to determine the relationship between hepatitis B flares and depression or anxiety, utilizing outpatient and inpatient data from the Taiwan National Health Insurance Research database collected from 2000 to 2015. Patients and Methods: A total of 12,992 patients with chronic hepatitis B and newly diagnosed anxiety/depression, without advanced liver disease, were propensity score-matched for age, sex, and comorbidities in a 1:4 ratio to 51,968 controls with chronic hepatitis B without depression/anxiety or advanced liver disease. Both groups were followed-up until December 31, 2015. Cox proportional hazards regression was used to determine the risk factors for hepatitis B flares. The Log rank test and Kaplan-Meier analysis were performed to assess differences in the cumulative incidence of hepatitis B flares according to anxiety/depression status. Results: The incidence of hepatitis B flares was higher in the depression/anxiety cohort than in the control cohort (log-rank; Conclusion: This analysis suggests that in patients with chronic hepatitis B without advanced liver disease, those with concomitant depression or anxiety may be at higher risk of hepatitis B flares.
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Registered trials
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