ArticleVirus evolution2022
Three new clades of putative viral RNA-dependent RNA polymerases with rare or unique catalytic triads discovered in libraries of ORFans from powdery mildews and the yeast of oenological interest
Article in Virus evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 40 citations in OpenAlex.
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- Diverse virome and potential pathogens in five tick species from metropolis surroundings of Beijing and Tianjin, China.NPJ biofilms and microbiomes · 2025Article
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- A hypovirulence-associated capsidless bi-segmented ssRNA mycovirus enhances melanin and microsclerotial production in a vascular phytopathogenic fungus.PLoS pathogens · 2025Article
- A group of segmented viruses contains genome segments sharing homology with multiple viral taxa.Journal of virology · 2025Article
- Summary of taxonomy changes ratified by the International Committee on Taxonomy of Viruses (ICTV) from the Fungal and Protist Viruses Subcommittee, 2025.The Journal of general virology · 2025Article
- In-depth analysis of 17,115 rice transcriptomes reveals extensive viral diversity in rice plants.Nature communications · 2025Article
- An orphan viral genome with unclear evolutionary status sheds light on a distinct lineage of flavi-like viruses infecting plants.Virus evolution · 2025Article
- The virome of the panglobal, wide host-range plant pathogenVirus evolution · 2025Article
- Uncovering hundreds of exogenous and endogenous RNA viral RdRp sequences amongst uncharacterized sequences in public protein databases.Virus evolution · 2025Article
- Dothistroma septosporum and Dothistroma pini, the causal agents of Dothistroma needle blight, are infected by multiple viruses.Virus research · 2024Article
- New insights into RNA mycoviruses of fungal pathogens causing Fusarium head blight.Virus research · 2024Article
- A virus associated with the zoonotic pathogenbioRxiv : the preprint server for biology · 2024Article
- Molecular characterization of the complete genome of a novel ormycovirus infecting the ectomycorrhizal fungus Hortiboletus rubellus.Archives of virology · 2024Article
- New clades of viruses infecting the obligatory biotrophVirus evolution · 2024Article
- Determination of the Mycovirome of a Necrotrophic Fungus.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Unveiling mycoviral diversity inFrontiers in microbiology · 2024Article
- A virus associated with the zoonotic pathogenVirus evolution · 2024Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High throughput sequencing allowed the discovery of many new viruses and viral organizations increasing our comprehension of virus origin and evolution. Most RNA viruses are currently characterized through similarity searches of annotated virus databases. This approach limits the possibility to detect completely new virus-encoded proteins with no detectable similarities to existing ones, i.e. ORFan proteins. A strong indication of the ORFan viral origin in a metatranscriptome is the lack of DNA corresponding to an assembled RNA sequence in the biological sample. Furthermore, sequence homology among ORFans and evidence of co-occurrence of these ORFans in specific host individuals provides further indication of a viral origin. Here, we use this theoretical framework to report the finding of three conserved clades of protein-coding RNA segments without a corresponding DNA in fungi. Protein sequence and structural alignment suggest these proteins are distantly related to viral RNA-dependent RNA polymerases (RdRP). In these new putative viral RdRP clades, no GDD catalytic triad is present, but the most common putative catalytic triad is NDD and a clade with GDQ, a triad previously unreported at that site. SDD, HDD, and ADD are also represented. For most members of these three clades, we were able to associate a second genomic segment, coding for a protein of unknown function. We provisionally named this new group of viruses ormycovirus. Interestingly, all the members of one of these sub-clades (gammaormycovirus) accumulate more minus sense RNA than plus sense RNA during infection.
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