Evidence map›Paper›PMID 35615059›Full record

ArticleBrain and neuroscience advances

Regulation of glutamate transport and neuroinflammation in a term newborn rat model of hypoxic-ischaemic brain injury.

Silvia Pregnolato, Hemmen Sabir, Karen Luyt, Kira DA Rienecker, Anthony R Isles, Elavazhagan Chakkarapani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and neuroscience advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Immune dysregulation and epileptogenesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Silvia PregnolatoDepartment of Neonatal Neurology, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-4124-2108
Hemmen SabirDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.
Karen LuytDepartment of Neonatal Neurology, Bristol Medical School, University of Bristol, Bristol, UK.
Kira DA RieneckerDepartment of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, USA.
Anthony R IslesBehavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-7587-5712
Elavazhagan ChakkarapaniDepartment of Neonatal Neurology, Bristol Medical School, University of Bristol, Bristol, UK.
University of Bristol · GBCardiff University · GBUniversity of Bonn · DEUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the newborn brain, moderate-severe hypoxia-ischaemia induces glutamate excitotoxicity and inflammation, possibly via dysregulation of candidate astrocytic glutamate transporter (

Indexed as

braincerebral ischaemiaglutamatehypoxia–ischaemiaHypoxic–ischemic encephalopathyneonatalneuroinflammationnewborn

Identifiers

PMID35615059
PMCPMC9125068
OpenAlexW4282945697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.