ReviewComputational and structural biotechnology journal2022
Statistical methods for Mendelian randomization in genome-wide association studies: A review.
Review in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
207 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Exploring the Relationship Between Antipsychotic Drug Target Genes and Epilepsy: Evidence From Food and Drug Administration Adverse Event Reporting System Database and Mendelian Randomization.Brain and behavior · 2025Pooled it
- Druggable genome-wide Mendelian randomization identifies therapeutic targets for metabolic dysfunction-associated steatotic liver disease.Lipids in health and disease · 2025Pooled it
- From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture.BMC oral health · 2025Pooled it
- Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian randomization.Journal of advanced research · 2025Pooled it
- Association of lipid-lowering drugs with risk of sarcopenia: a drug target mendelian randomization study and meta-analysis.Human genomics · 2024Pooled it
- Basal metabolic rate and the risk of urolithiasis: a two-sample Mendelian randomization study.World journal of urology · 2024Pooled it
- Mendelian randomization studies of lifestyle-related risk factors for stroke: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis.Frontiers in immunology · 2024Pooled it
- Genetic predisposition to white blood cells in relation to the risk of frailty.Aging clinical and experimental research · 2023Pooled it
- Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases.Frontiers in immunology · 2023Pooled it
- How gut microbiome and blood metabolites drive ossification of the posterior longitudinal ligament of the spine: a genome-wide association study based on the East Asian population.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Exploratory bidirectional Mendelian randomisation analysis of cerebrospinal fluid metabolites associated with cerebral palsy and epilepsy.BMJ paediatrics open · 2026Article
- Integrative analysis prioritizes proteins associated with renal cell carcinoma and its risk factors.JNCI cancer spectrum · 2026Article
- A flexible framework for robust and efficient Mendelian randomization with debiasing.Briefings in bioinformatics · 2026Article
- Brain imaging-wide exploration of site-specific pain: genetic correlation and Mendelian randomization study.Psychological medicine · 2026Article
- PCSK9 inhibitors do not increase cognitive risk.Biology direct · 2026Article
- Causal genes for osteoporosis: Mendelian randomization analysis with multilayer xQTL data.Medicine · 2026Article
- Oral Microbiota and Cardiovascular Diseases: A Study Integrating Genome-Wide Association and 16S rRNA Sequence Analyses.International dental journal · 2026Article
- Observational
- Simulated sample splitting approach to address biases due to instrument selection and participant overlap in two-sample Mendelian Randomization studies.PLoS genetics · 2026Article
147 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Genome-wide association studies have yielded thousands of associations for many common diseases and disease-related complex traits. The identified associations made it possible to identify the causal risk factors underlying diseases and investigate the causal relationships among complex traits through Mendelian randomization. Mendelian randomization is a form of instrumental variable analysis that uses SNP associations from genome-wide association studies as instruments to study and uncover causal relationships between complex traits. By leveraging SNP genotypes as instrumental variables, or proxies, for the exposure complex trait, investigators can tease out causal effects from observational data, provided that necessary assumptions are satisfied. We discuss below the development of Mendelian randomization methods in parallel with the growth of genome-wide association studies. We argue that the recent availability of GWAS summary statistics for diverse complex traits has motivated new Mendelian randomization methods with relaxed causality assumptions and that this area continues to offer opportunities for robust biological discoveries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.