Evidence map›Paper›PMID 35615020›Full record

ArticleComputational and structural biotechnology journal2022

Computational epitope binning reveals functional equivalence of sequence-divergent paratopes.

Jarjapu Mahita, Dong-Gun Kim, Sumin Son, Yoonjoo Choi, Hak-Sung Kim, Chris Bailey-Kellogg

Abstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jarjapu MahitaDepartment of Computer Science, Dartmouth College, Hanover, NH 03755, USA.
Dong-Gun KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Sumin SonDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Yoonjoo ChoiCombinatorial Tumor Immunotherapy MRC, Chonnam National University Medical School, Hwasun-gun, Jeollanam-do 58128, Republic of Korea.
Hak-Sung KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Chris Bailey-KelloggDepartment of Computer Science, Dartmouth College, Hanover, NH 03755, USA.

Funding

Functional Deimmunization of Therapeutic ProteinsR01GM098977 · NIGMS · DARTMOUTH COLLEGE · PI BAILEY-KELLOGG, CHRIS, GRISWOLD, KARL E · 2011 to 2019
$3.4M
NIGMS NIH HHS R01 GM098977
6 · The paper itself

Abstract

The therapeutic efficacy of a protein binder largely depends on two factors: its binding site and its binding affinity. Advances in

Indexed as

AU-PRC, Area under the precision-recall curveDockingEpitopeEpitope binningIL-6, Interleukin - 6LRR, leucine-rich repeatParatope equivalencePCC, Pearson correlation coefficientPro, ProlineProtein binderRepebodyRMSD, Root-mean squared deviationSARS-CoV-2, severe acute respiratory syndrome coronavirus – 2

Identifiers

PMID35615020
PMCPMC9118127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.