Evidence map›Paper›PMID 35615012›Full record

ArticleBioMed research international2022

Activating IL-6/STAT3 Enhances Protein Stability of Proteasome 20S

Weiguo Ren, Xuexiu Zhang, Qiang Li, Chibin Pu, Decai Zhang

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Weiguo RenDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.ORCID https://orcid.org/0000-0002-4678-4360
Xuexiu ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.
Qiang LiOncology Department, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518101, China.
Chibin PuDepartment of Gastroenterology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, China.
Decai ZhangDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
First Affiliated Hospital of Zhengzhou University · CNCentral South University · CNSouthern Medical University Shenzhen Hospital · CNZhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A widely recognized feature of colorectal cancer (CRC) is an increase in cytokine levels, which result in an inflammatory environment in the tumor. Interleukin-6 (IL-6) is a robust protumor cytokine. Several studies suggest that IL-6 plays a role in the development of tumors. Most intracellular protein breakdown occurs in eukaryotes via the ubiquitin-proteasome pathway; this mechanism may also be involved in cancer pathogenesis. The tumor tissues and paracancerous tissues were collected from 90 patients with colorectal cancer. The expressions of pSTAT3, proteasome 20S

Indexed as

Colorectal NeoplasmsInterleukin-6MicroRNAsProteasome Endopeptidase ComplexSTAT3 Transcription FactorAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMiceProspective StudiesProtein StabilityProto-Oncogene ProteinsInterleukin-6MicroRNAsMIRN1254 microRNA, humanProteasome Endopeptidase ComplexProto-Oncogene ProteinsPSMD10 protein, humanSTAT3 protein, humanSTAT3 Transcription Factor

Identifiers

PMID35615012
PMCPMC9125429
OpenAlexW4280541666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.