Evidence map›Paper›PMID 35614842›Full record

ArticlePhotochemistry and photobiology2023

No Evidence of Induced Skin Cancer or Other Skin Abnormalities after Long-Term (66 week) Chronic Exposure to 222-nm Far-UVC Radiation.

David Welch, Norman J Kleiman, Peter C Arden, Christine L Kuryla, Manuela Buonanno, Brian Ponnaiya, Xuefeng Wu, David J Brenner

Abstract read
In one paragraph

Article in Photochemistry and photobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Managing infectious aerosols to counter engineered pandemics: Current recommendations and future research.Risk analysis : an official publication of the Society for Risk Analysis · 2025
    Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Dermatological effects of acute and long-term UV-C exposure: an in vivo study using a portable mercury lamp.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Far-UVC Radiation for Disinfecting Hands or Gloves?Pathogens (Basel, Switzerland) · 2023
    Article
  16. Article
  17. Active Air Interventions.The Bridge · 2022
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David Welch *Center for Radiological Research, Columbia University Irving Medical Center, New York, New York.ORCID https://orcid.org/0000-0003-2784-496X
Norman J Kleiman *Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York.
Peter C ArdenDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York.
Christine L KurylaDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York.
Manuela BuonannoCenter for Radiological Research, Columbia University Irving Medical Center, New York, New York.ORCID https://orcid.org/0000-0002-3455-3602
Brian PonnaiyaCenter for Radiological Research, Columbia University Irving Medical Center, New York, New York.
Xuefeng WuCenter for Radiological Research, Columbia University Irving Medical Center, New York, New York.
David J BrennerCenter for Radiological Research, Columbia University Irving Medical Center, New York, New York.

Funding

Monochromatic 222 nm UV light: Development of a safe, cost-effective technology for the efficient reduction of bacterial and viral infection and transmissionR42AI125006 · NIAID · EDEN PARK ILLUMINATION, INC. · PI BRENNER, DAVID JONATHAN, PARK, SUNG-JIN · 2019 to 2020
$996k
BoeingNational Institute of Allergy and Infectious Diseases 5R42AI125006NIAID NIH HHS R42 AI125006Shostack Foundation
6 · The paper itself

Abstract

Far-UVC radiation, typically defined as 200-235 nm, has similar or greater anti-microbial efficacy compared with conventional 254-nm germicidal radiation. In addition, biophysical considerations of the interaction of far-UVC with tissue, as well as multiple short-term safety studies in animal models and humans, suggest that far-UVC exposure may be safe for skin and eye tissue. Nevertheless, the potential for skin cancer after chronic long-term exposure to far-UVC has not been studied. Here, we assessed far-UVC induced carcinogenic skin changes and other pathological dermal abnormalities in 96 SKH-1 hairless mice of both sexes that were exposed to average daily dorsal skin doses of 400, 130 or 55 mJ cm

Indexed as

Skin AbnormalitiesSkin NeoplasmsAnimalsFemaleHumansMaleMiceMice, HairlessSkinUltraviolet Rays

Identifiers

PMID35614842
PMCPMC9691791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.