ArticleMovement disorders : official journal of the Movement Disorder Society2022
Dynamics of Nigral Iron Accumulation in Parkinson's Disease: From Diagnosis to Late Stage.
Article in Movement disorders : official journal of the Movement Disorder Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 41 citations in OpenAlex.
- Reimagining the contribution of iron in Parkinson's disease.Neurobiology of disease · 2026Review
- Sub-voxel QSM reveals the mechanism linking substantia nigra iron and temporal diamagnetism to PD gait.NPJ Parkinson's disease · 2026Article
- HFE genotype influences substantia nigra iron accumulation and Parkinson's disease progression.medRxiv : the preprint server for health sciences · 2026Article
- Levodopa increases substantia nigra iron: implications for Parkinson's disease.bioRxiv : the preprint server for biology · 2026Article
- L-DOPA influences transferrin-dependent iron release at the blood-brain barrier.Fluids and barriers of the CNS · 2026Article
- When Pathways Converge: Iron, Lipid Peroxidation, and α-Synuclein in Ferroptosis-Driven Dopaminergic Neurodegeneration.Journal of neurochemistry · 2026Review
- Sex and Diet Biased Effect of L-DOPA on Iron Accumulation in the Ventral Midbrain.Journal of neurochemistry · 2026Article
- Isn't it ironic? Functional iron deficiency at the core of Parkinson's disease pathobiology.The Journal of clinical investigation · 2026Article
- The role of quantitative susceptibility mapping in dementia with Lewy Bodies.NeuroImage. Clinical · 2026Article
- Cranial glucose metabolic patterns across prodromal and clinical parkinson's disease revealed byEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Association between brain iron deposition and pure apathy in Parkinson's disease: a cross-sectional quantitative susceptibility mapping imaging study.Quantitative imaging in medicine and surgery · 2025Article
- Imaging of Cerebral Iron as an Emerging Marker for Brain Aging, Neurodegeneration, and Cerebrovascular Diseases.Brain sciences · 2025Review
- Nigrostriatal iron accumulation in the progression of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases.Signal transduction and targeted therapy · 2025Review
- Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo.Brain pathology (Zurich, Switzerland) · 2024Article
- Neuropathological findings and in vivo imaging correlates of the red nucleus compared to those of the substantia nigra pars compacta in parkinsonisms.Parkinsonism & related disorders · 2024Article
- Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals.Nature communications · 2024Article
- Article
- The Irony of Iron: The Element with Diverse Influence on Neurodegenerative Diseases.International journal of molecular sciences · 2024Review
- Iron Deposition in Parkinson's Disease: A Mini-Review.Cellular and molecular neurobiology · 2024Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHigher nigral iron has been reported in Parkinson's disease (PD).
objectiveThe aim is to understand the dynamics of nigral iron accumulation in PD and its association with drug treatment.
methodsSusceptibility magnetic resonance imaging data were obtained from 79 controls and 18 drug-naive (PD
resultsCompared to controls, PD
conclusionNigral iron is lower before the start of dopaminergic medication and then increases throughout the disease until it plateaus at late stages, suggesting increased iron may not be an etiological factor. Interestingly, PD medications may have differential associations with iron accumulation that need further investigation. © 2022 International Parkinson and Movement Disorder Society.
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Registered trials
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