ArticleScientific reports2022
Effect of heat exposure on the growth and developmental competence of bovine oocytes derived from early antral follicles.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The effects of heat stress on the ovary, follicles, and oocytes: a systematic review†.Biology of reproduction · 2025Pooled it
- Heterogeneity in secondary follicle development buffers the lifespan of activated oocytes to optimize female fertility in mice.Nature aging · 2026Article
- E4BP4 interacts with PERK to form a feedback loop mediating cold-induced female reproductive disorders.Cell stress & chaperones · 2026Article
- Holding temperature to transport immature bovine oocytes in collection media critically affects their developmental competence.The Journal of reproduction and development · 2026Article
- The association between heat waves and pregnancy outcome among women undergoing assisted reproductive technology in Sichuan, China.BMC public health · 2026Article
- In vivo use of melatonin improves oocyte developmental competence and blastocyst development rate in indigenous donor cow during summer.Tropical animal health and production · 2026Article
- Effect of Low-Temperature Plasma on Porcine Oocytes In Vitro Primary Culture.Antioxidants (Basel, Switzerland) · 2026Article
- Molecular and developmental consequences of heat stress on the bovine oocyte and embryo competence.Animal reproduction · 2026Article
- Heat-Induced Pathophysiological and Metabolic Changes at the Feto-Maternal Interface Predisposing to Preterm Birth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Reproductive Challenges in Ruminants Under Heat Stress: A Review of Follicular, Oocyte, and Embryonic Responses.Animals : an open access journal from MDPI · 2025Review
- Effects of heat stress on gene expression associated with antioxidant capacity of bovine early antral follicles.The Journal of veterinary medical science · 2025Article
- Optimization of ovum pick-up-in vitro fertilization and in vitro growth of immature oocytes in ruminants.The Journal of reproduction and development · 2025Review
- Follicular fluid extracellular vesicles improve bovine oocyte quality via lipid and mitochondrial modulation.Frontiers in veterinary science · 2025Article
- Impact of Heat Stress on Oocyte Developmental Competence and Pre-Implantation Embryo Viability in Cattle.Animals : an open access journal from MDPI · 2024Review
- Effects of orange peel extract (Veterinary world · 2024Article
- Physiological high temperatures alter the amino acid metabolism of bovine early antral follicles.The Journal of reproduction and development · 2024Article
- Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis.Antioxidants (Basel, Switzerland) · 2024Review
- Article
- Heat Stress as a Barrier to Successful Reproduction and Potential Alleviation Strategies in Cattle.Animals : an open access journal from MDPI · 2023Review
- Disorder of Biological Quality and Autophagy Process in Bovine Oocytes Exposed to Heat Stress and the Effectiveness of In Vitro Fertilization.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In dairy cows, low fertility caused by summer heat stress continues into the cooler autumn season. This can be caused by impaired oocyte quality in small growing follicles during summer. Here, we subjected oocyte-cumulus-granulosa complexes (OCGCs) derived from early antral follicles (0.5-1 mm) to in vitro growth (IVG) culture under two different temperature settings (the control and heat shock groups), and evaluated effects of heat exposure on growth and developmental competence of oocytes, factors affecting the developmental competence of oocytes (steroidogenesis of granulosa cells, oxidative stress in oocytes, and cell-to-cell communication between oocytes and somatic cells). Oocyte diameters after culture were smaller in the heat shock group. Although nuclear maturation and cleavage rates were similar between the groups, blastocyst rates were lower in the heat shock group (0.0%) than in the control group (27.7%), and reduced glutathione (GSH) levels in oocytes were lower in the heat shock group. Supplementation of cysteine, which stimulates GSH synthesis, increased GSH level and improved blastocyst rate of heat shocked oocytes (27.9%). These results suggest that heat exposure impairs the growth and developmental competence of oocytes in early antral follicles through GSH depletion, which can induce low fertility during summer and the following autumn.
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