Evidence map›Paper›PMID 35614267›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Imaging PARP with [

Chung Ying Chan, Zijun Chen, Gianluca Destro, Mathew Veal, Doreen Lau, Edward O'Neill, Gemma Dias, Michael Mosley, Veerle Kersemans, Florian Guibbal and 2 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Current status of radionuclide therapy targeting PARP in cancer: challenges and prospects.European journal of nuclear medicine and molecular imaging · 2026
    Review
  2. Review
  3. Development and evaluation of aEJNMMI radiopharmacy and chemistry · 2025
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. [Journal of clinical medicine · 2024
    Review
  9. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  10. Review
  11. Targeted Alpha-Particle Therapy: A Review of Current Trials.International journal of molecular sciences · 2023
    Review
  12. PET imaging of PARP expression usingEuropean journal of nuclear medicine and molecular imaging · 2023
    Article
  13. Article
  14. [Radiology. Imaging cancer · 2022
    Article
  15. Article
4 · The record

Corrections and comments

  • Commented on by
    [2022
5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Chung Ying ChanOxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Off Roosevelt Drive, OX3 7DQ, Oxford, UK.
Zijun ChenDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Gianluca DestroDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Mathew VealOxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Off Roosevelt Drive, OX3 7DQ, Oxford, UK.
Doreen LauOxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Off Roosevelt Drive, OX3 7DQ, Oxford, UK.
Edward O'NeillOxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Off Roosevelt Drive, OX3 7DQ, Oxford, UK.
Gemma DiasOxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Off Roosevelt Drive, OX3 7DQ, Oxford, UK.
Michael MosleyOxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Off Roosevelt Drive, OX3 7DQ, Oxford, UK.
Veerle KersemansOxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Off Roosevelt Drive, OX3 7DQ, Oxford, UK.
Florian GuibbalDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Véronique GouverneurDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Bart CornelissenOxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Off Roosevelt Drive, OX3 7DQ, Oxford, UK. bart.cornelissen@oncology.ox.ac.uk.ORCID 0000-0001-7581-3303
University of Oxford · GBUniversity Medical Center Groningen · NL

Funding

Cancer Research UK 16466Cancer Research UK 23970Medical Research Council MR/R01695X/1Medical Research Council MR/S008209/1
6 · The paper itself

Abstract

purposeRucaparib, an FDA-approved PARP inhibitor, is used as a single agent in maintenance therapy to provide promising treatment efficacy with an acceptable safety profile in various types of BRCA-mutated cancers. However, not all patients receive the same benefit from rucaparib-maintenance therapy. A predictive biomarker to help with patient selection for rucaparib treatment and predict clinical benefit is therefore warranted. With this aim, we developed [

methodWe incorporated the positron-emitting

resultsUptake of [

conclusionTaken together, we demonstrate the potential of [

Indexed as

Antineoplastic AgentsPancreatic NeoplasmsAnimalsHumansIndolesMicePoly(ADP-ribose) Polymerase InhibitorsAntineoplastic AgentsIndolesPoly(ADP-ribose) Polymerase Inhibitorsrucaparib[18F]RucaparibPancreatic cancerPARPPET imagingRucaparib

Identifiers

PMID35614267
PMCPMC9399069
OpenAlexW4281561745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.