ArticleNature2022
Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
14.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- Hydrated proton complexes supplementation for tumor microenvironment reprogramming: a bioenergetic strategy targeting the Warburg effect and mitochondrial dysfunction.Frontiers in oncology · 2025Pooled it
- Article
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Molecular mechanisms of mitochondrial uncoupling: focus on 2,4-dinitrophenol.European biophysics journal : EBJ · 2026Review
- Enzymatic oxygen reduction dominates overpotential-driven thermogenesis in mitochondria.Chemical science · 2026Article
- Decoding the Hot-Mitochondrion Paradox.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Article
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- Heart-homed nanomedicine induces fast mitochondrial rescue to enhance cardiac function post-myocardial infarction.Bioactive materials · 2026Article
- Fatty acids promote uncoupled respiration via ATP/ADP carriers in white adipocytes.Nature metabolism · 2026Article
- Article
- Investigation of mitochondrial inner membrane ion conductance by planar lipid bilayer electrophysiology.Frontiers in physiology · 2026Article
- Altered mitochondrial functionality in metabolic disorders: insights fromFrontiers in endocrinology · 2026Review
- Energy metabolic dysregulation in heat stroke: from mitochondrial dysfunction to multi-organ failure mechanisms and targeted intervention.Frontiers in pharmacology · 2026Review
- Adapter-based allogeneic CAR T cells to overcome antigen escape in solid tumors.Frontiers in immunology · 2026Review
- Deciphering Uncoupling Proteins in Cellular Homeostasis and Metabolic Health.International journal of biological sciences · 2026Review
- Mitochondria as a Therapeutic Target in Metabolic Disorders.Mini reviews in medicinal chemistry · 2026Review
- Imaging of mitochondrial matrix pH dynamics reveals a functional interaction between the ADP/ATP carrier and ATP synthase to regulate HPharmacological research · 2025Article
- Interactions of Arachidonic Acid with AAC1 and UCP1.International journal of molecular sciences · 2025Article
- Mitochondrial uncoupling, energy substrate utilization, and brown adipose tissue as therapeutic targets in cancer.npj metabolic health and disease · 2025Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Ambre M Bertholet *Department of Physiology, University of California San Francisco, San Francisco, CA, USA.
Andrew M Natale *Cardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6320-0216
Paola BisignanoCardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Junji SuzukiDepartment of Physiology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1648-5471
Andriy FedorenkoDepartment of Physiology, University of California San Francisco, San Francisco, CA, USA.
James HamiltonDepartment of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA.
Tatiana BrustovetskyDepartment of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA.
Lawrence KazakDana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7591-2544
Ryan GarrityDana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5015-4505
Edward T ChouchaniDana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9776-8790
Nickolay BrustovetskyDepartment of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-6564-2560
Michael GrabeCardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA. Michael.Grabe@ucsf.edu.ORCID http://orcid.org/0000-0003-3509-5997
Yuriy KirichokDepartment of Physiology, University of California San Francisco, San Francisco, CA, USA. Yuriy.Kirichok@ucsf.edu.ORCID http://orcid.org/0000-0001-7155-843X
University of California, San Francisco · USHarvard University · USIndiana University – Purdue University Indianapolis · USUniversity of California, Los Angeles · US
Funding
STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1MMolecular Biophysics of Mitochondrial MembranesR35GM136415 · NIGMS · WASHINGTON UNIVERSITY · PI Yuriy Kirichok · 2020 to 2026
$4.7MCRMP2, mitochondria, and Huntington’s diseaseR01NS098772 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI BRUSTOVETSKY, NICKOLAY, KHANNA, RAJESH · 2017 to 2021
$2.8MComputational Studies of Sodium SymportersR01GM089740 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRABE, MICHAEL · 2011 to 2020
$2.8MMechanisms of regulation of mitochondrial H+ leak and thermogenesisR35GM143097 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERTHOLET, AMBRE MARGUERITE SOLANGE · 2021 to 2025
$1.9MMolecular Mechanisms of Mitochondrial Uncoupling and ThermogenesisR01GM118939 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIRICHOK, YURIY · 2017 to 2020
$1.8MMitochondrial Uncoupling and Thermogenesis in Adipose TissuesR01GM107710 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIRICHOK, YURIY · 2015 to 2018
$1.6MIon permeation, lipid flipping, and membrane remodeling by TMEM16 proteinsR01GM137109 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRABE, MICHAEL · 2021 to 2024
$1.4MHigh Performance Computer for Computational BiosciencesS10OD021596 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALI, ANDREJ · 2016 to 2016
$443kAmerican Heart Association-American Stroke AssociationNIGMS NIH HHS R01 GM089740NIGMS NIH HHS R01 GM107710NIGMS NIH HHS R01 GM118939NIGMS NIH HHS R01 GM137109NIGMS NIH HHS R35 GM136415NIGMS NIH HHS R35 GM143097NIGMS NIH HHS T32 GM008284NIH HHS S10 OD021596NINDS NIH HHS R01 NS098772
Abstract
Mitochondria generate heat due to H
Indexed as
MitochondriaMitochondrial ADP, ATP TranslocasesProtonsUncoupling Protein 1Adenosine DiphosphateAdenosine TriphosphateAdipose Tissue, BrownCarbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneFatty AcidsAdenosine DiphosphateAdenosine TriphosphateCarbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneFatty AcidsMitochondrial ADP, ATP TranslocasesProtonsUncoupling Protein 1
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.