ArticleNature2022
Defining mitochondrial protein functions through deep multiomic profiling.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 114 citations in OpenAlex.
- The mechanism of vascular injury caused by polystyrene microplastics: Involving ferroptosis and metabolomics.iScience · 2026Article
- Discovery urinary metabolomics of preterm neonatal acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2026Observational
- The predicted interactome of the human mitochondrial proteome.Nature communications · 2026Article
- Guanosine 10 methylation by TRMT11-TRMT112 optimizes human mitochondrial tRNAs for efficient translation.Nucleic acids research · 2026Article
- LipiDetective: a deep learning model for the identification of molecular lipid species in tandem mass spectra.Briefings in bioinformatics · 2026Article
- STREMI: a dual-function upstream ORF-encoded regulator of mitochondrial cristae architecture.EMBO reports · 2026Article
- Fmp30p is a mitochondrial phosphatidylinositol hydrolase that modulates CoQ biosynthesis.Nature communications · 2026Article
- Mitochondrial dynamics in neurodevelopment and neurodevelopmental disorders.Nature reviews. Neuroscience · 2026Review
- A graph-based learning approach to predict the effects of gene perturbations on molecular phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Function and regulation of the mitochondrial stress response.Nature structural & molecular biology · 2026Review
- Cooperative Architecture of Mitochondrial Proteome Homeostasis.medRxiv : the preprint server for health sciences · 2026Article
- Aging-linked systemic lipid signature is reprogrammed by caloric restriction in rhesus monkeys.Molecular systems biology · 2026Article
- Article
- Pharmaceutical Roots to Mitochondrial Routes: Targeting Neurodegeneration.Pharmaceutical research · 2026Review
- MECP2 Duplication Uncouples Mitochondrial and Purine Metabolism During neuronal maturation.bioRxiv : the preprint server for biology · 2025Article
- PRDM1-driven SLC30A9 overexpression contributes to the malignant phenotype of cervical cancer cells via promoting mitochondrial hyperfunction.Cell death & disease · 2025Article
- Endothelial RAB5IF is required for pathological and developmental retinal angiogenesis.Nature communications · 2025Article
- The integral membrane protein smim4 modulates redox balance via malate compartmentalization in pancreatic cancer.Nature communications · 2025Article
- Article
- The Role of Mitochondria-Associated Endoplasmic Reticulum Membranes in Fibrotic Diseases.Aging and disease · 2025Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors at 9 institutions in 3 countries.
Jarred W Rensvold *Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.
Evgenia Shishkova *National Center for Quantitative Biology of Complex Systems, Madison, WI, USA.
Yuriy SverchkovDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-9851-8582
Ian J MillerNational Center for Quantitative Biology of Complex Systems, Madison, WI, USA.
Arda CetinkayaDepartment of Medical Genetics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.ORCID http://orcid.org/0000-0002-3528-9495
Angela PyleWellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, UK.
Mateusz ManickiDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.
Dain R BrademanMorgridge Institute for Research, Madison, WI, USA.ORCID http://orcid.org/0000-0002-0971-9711
Yasemin AlanayDepartment of Pediatrics, Pediatric Genetics Unit, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Julian RaimanDepartment of Clinical Inherited Metabolic Disorders, Birmingham Women's and Children's Hospital NHS Trust, Birmingham, UK.
Adam JochemMorgridge Institute for Research, Madison, WI, USA.
Paul D HutchinsDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Sean R PetersDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Vanessa LinkeDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-1827-577X
Katherine A OvermyerMorgridge Institute for Research, Madison, WI, USA.ORCID http://orcid.org/0000-0002-1929-1229
Austin Z SalomeDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-7360-3759
Alexander S HebertNational Center for Quantitative Biology of Complex Systems, Madison, WI, USA.
Catherine E VincentDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Nicholas W KwiecienNational Center for Quantitative Biology of Complex Systems, Madison, WI, USA.
Matthew J P RushDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-5622-1350
Michael S WestphallNational Center for Quantitative Biology of Complex Systems, Madison, WI, USA.
Mark CravenDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-8917-7464
Nurten A AkarsuDepartment of Medical Genetics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.ORCID http://orcid.org/0000-0001-5432-0032
Robert W TaylorWellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-7768-8873
Joshua J CoonMorgridge Institute for Research, Madison, WI, USA. jcoon@chem.wisc.edu.ORCID http://orcid.org/0000-0002-0004-8253
David J PagliariniDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA. pagliarini@wustl.edu.ORCID http://orcid.org/0000-0002-0001-0087
University of Wisconsin–Madison · USHacettepe University · TRWashington University in St. Louis · USBirmingham Women’s and Children’s NHS Foundation Trust · GBKent Hastanesi · TRMorgridge Institute for Research · USNewcastle upon Tyne Hospitals NHS Foundation Trust · GBUniversity of Wisconsin System · USWellcome Centre for Mitochondrial Research · GB
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MTR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1MTrainingU54AI117924 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI CRAVEN, MARK W. · 2014 to 2018
$11.3MSystems-to-structure approaches for defining mitochondrial protein functionR35GM131795 · NIGMS · WASHINGTON UNIVERSITY · PI David J Pagliarini · 2019 to 2026
$4.8MMedical Research Council G0800674Medical Research Council MR/S005021/1NIAID NIH HHS U54 AI117924NIDDK NIH HHS P30 DK056341NIGMS NIH HHS P41 GM108538NIGMS NIH HHS R35 GM131795Wellcome TrustWellcome Trust 203105/Z/16/Z
Abstract
Mitochondria are epicentres of eukaryotic metabolism and bioenergetics. Pioneering efforts in recent decades have established the core protein componentry of these organelles
Indexed as
MitochondriaMitochondrial ProteinsCation Transport ProteinsCell Cycle ProteinsEnergy MetabolismHumansMass SpectrometryMitochondrial Diseasesrab5 GTP-Binding ProteinsTranscription FactorsCation Transport ProteinsCell Cycle ProteinsMitochondrial ProteinsRAB5C protein, humanrab5 GTP-Binding ProteinsSLC30A9 protein, humanTranscription Factors
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.