ArticleNature2022
CCR5 closes the temporal window for memory linking.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 110 citations in OpenAlex.
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- The Role of the CCR5 Receptor in Neuropathic Pain Modulation: Current Insights and Therapeutic Implications.Biomedicines · 2025Review
- Neuropsychiatric- and cognitive post-acute sequelae of SARS-CoV-2 infection - evidence from K18-hACE C57BL/6 J mice.The international journal of neuropsychopharmacology · 2025Article
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- Erasable hippocampal neural signatures predict memory discrimination.Cell reports · 2025Article
- Compartmentalized dendritic plasticity in the mouse retrosplenial cortex links contextual memories formed close in time.Nature neuroscience · 2025Article
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Corrections and comments
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Authors and funding
22 authors at 3 institutions in 2 countries.
Yang Shen *Neurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6055-5046
Miou Zhou *Neurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA. mzhou@westernu.edu.ORCID http://orcid.org/0000-0001-8188-7392
Denise CaiNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7729-0523
Daniel Almeida FilhoNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3583-3796
Giselle FernandesNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.
Ying CaiNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.
André F de SousaNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2613-1546
Min TianDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-0460-4584
Nury KimCenter for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea.
Jinsu LeeDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Deanna NeculaNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.
Chengbin ZhouNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.
Shuoyi LiNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.
Shelbi SalinasGraduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA.
Andy LiuNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.
Xiaoman KangNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.
Masakazu KamataDepartment of Hematology and Oncology, University of California Los Angeles, Los Angeles, CA, USA.
Ayal LaviNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.
Shan HuangNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.
Tawnie SilvaNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA.
Won Do HeoDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0001-7541-7319
Alcino J SilvaNeurobiology, Psychiatry and Psychology Departments and Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA, USA. silvaa@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-1587-4558
University of California, Los Angeles · USKorea Advanced Institute of Science and Technology · KRWestern University of Health Sciences · US
Funding
UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUSAN Y BOOKHEIMER · 2020 to 2026
$9.6MMolecular, Cellular and Circuit Mechanisms for Age-Related Deficits in Memory-LinkingRF1AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2022
$4.9MCCR5 Activation and Cognitive Dysfunction Caused by HIV-ProteinsR01NS106969 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2021
$3.7MMolecular, Cellular and Circuit Mechanisms for Age-Related Deficits in Memory-LinkingR01AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani · 1995 to 2026
$3.3MBuilding and sharing next generation open-source, wireless, multichannel miniaturized microsopes for imaging activity in freely behaving miceU01NS094286 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLSHANI, PEYMAN, KHAKH, BALJIT · 2015 to 2017
$2.7MMolecular, Cellular and Circuit Mechnisms for Memory-linking deficits in Psychiatric DisordersR01MH113071 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2021
$2.3MNIA NIH HHS R01 AG013622NIA NIH HHS RF1 AG013622NICHD NIH HHS P50 HD103557NIMH NIH HHS R01 MH113071NINDS NIH HHS R01 NS106969
Abstract
Real-world memories are formed in a particular context and are often not acquired or recalled in isolation
Indexed as
CA1 Region, HippocampalMemoryNeuronsReceptors, CCR5AnimalsMental RecallMiceTime FactorsCCR5 protein, mouseReceptors, CCR5
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.