Evidence map›Paper›PMID 35614218›Full record

ArticleNature2022

Generation of specialized blood vessels via lymphatic transdifferentiation.

Rudra N Das, Yaara Tevet, Stav Safriel, Yanchao Han, Noga Moshe, Giuseppina Lambiase, Ivan Bassi, Julian Nicenboim, Matthias Brückner, Dana Hirsch and 5 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
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  13. Article
  14. Endothelial cell transitions in zebrafish vascular development.Development, growth & differentiation · 2024
    Review
  15. Science advances · 2024
    Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Rudra N DasDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel. rudra-nayan.das@weizmann.ac.il.ORCID http://orcid.org/0000-0002-4607-6081
Yaara TevetDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Stav SafrielDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Yanchao HanDuke Regeneration Center, Department of Cell Biology, Duke University School of Medicine, Durham, NC, United States.ORCID http://orcid.org/0000-0002-1838-0836
Noga MosheDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Giuseppina LambiaseDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Ivan BassiDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Julian NicenboimDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Matthias BrücknerMax Plank Institute for Molecular Biomedicine, Muenster, Germany.
Dana HirschDepartment of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
Raya Eilam-AltstadterDepartment of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
Wiebke HerzogMax Plank Institute for Molecular Biomedicine, Muenster, Germany.
Roi AvrahamDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Kenneth D PossDuke Regeneration Center, Department of Cell Biology, Duke University School of Medicine, Durham, NC, United States.ORCID http://orcid.org/0000-0002-6743-5709
Karina YanivDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel. karina.yaniv@weizmann.ac.il.ORCID http://orcid.org/0000-0001-5638-7150
Weizmann Institute of Science · ILDuke University · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEMax Planck Institute for Molecular Biomedicine · DE

Funding

Leveraging zebrafish models to dissect and enhance heart regenerationR35HL150713 · NHLBI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI KENNETH D POSS · 2020 to 2026
$6.9M
Regulation of Appendage Regeneration in ZebrafishR01HD105033 · NICHD · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI POSS, KENNETH D · 2021 to 2025
$2.0M
European Research Council 756653European Research Council 818858NHLBI NIH HHS R35 HL150713NICHD NIH HHS R01 HD105033
6 · The paper itself

Abstract

The lineage and developmental trajectory of a cell are key determinants of cellular identity. In the vascular system, endothelial cells (ECs) of blood and lymphatic vessels differentiate and specialize to cater to the unique physiological demands of each organ

Indexed as

Blood VesselsCell TransdifferentiationLymphatic VesselsAnimal FinsAnimalsCell LineageEndothelial CellsZebrafish

Identifiers

PMID35614218
PMCPMC9875863
OpenAlexW4281476912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.