Evidence map›Paper›PMID 35614217›Full record

ArticleNature2022

Neuropathic pain caused by miswiring and abnormal end organ targeting.

Vijayan Gangadharan, Hongwei Zheng, Francisco J Taberner, Jonathan Landry, Timo A Nees, Jelena Pistolic, Nitin Agarwal, Deepitha Männich, Vladimir Benes, Moritz Helmstaedter and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.

  1. Pooled it
  2. Discovery of a peripherally restricted αCell reports. Medicine · 2026
    Article
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  5. Article
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  8. Review
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  13. Article
  14. Review
  15. Review
  16. Article
  17. Nano-Anesthetics Regulate Neuro-Immune Interaction for Treating Neuropathic Pain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  18. Article
  19. Mechanism-based nonopioid analgesic targets.The Journal of clinical investigation · 2025
    Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Vijayan GangadharanInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-2385-045X
Hongwei ZhengDepartment of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-6657-9105
Francisco J TabernerInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Jonathan LandryGenomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2262-9099
Timo A NeesInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Jelena PistolicGenomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.
Nitin AgarwalInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Deepitha MännichInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8990-3518
Vladimir BenesGenomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-0352-2547
Moritz HelmstaedterMax Planck Institute for Brain Research, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0001-7973-0767
Björn OmmerInterdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany.
Stefan G LechnerInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9402-9127
Thomas KunerDepartment of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.
Rohini KunerInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany. rohini.kuner@pharma.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-3333-9129
Heidelberg University · DEEuropean Molecular Biology Laboratory · DEMax Planck Institute for Brain Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nerve injury leads to chronic pain and exaggerated sensitivity to gentle touch (allodynia) as well as a loss of sensation in the areas in which injured and non-injured nerves come together

Indexed as

HyperalgesiaNeuralgiaNociceptorsSkinAnimalsChronic PainMechanoreceptorsMice

Identifiers

PMID35614217
PMCPMC9159955
OpenAlexW4281477906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.