ArticleNature2022
Divergent transcriptional regulation of astrocyte reactivity across disorders.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 109 papers.
0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 156 citations in OpenAlex.
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- Epigenetic mechanisms in traumatic brain injury: a focus on astrocytes and therapeutic implications.Journal of neuroinflammation · 2026Review
- PBAE nanoparticle-mediated delivery of ASCL1 and NGN2 genes for astroglia-to-neuron reprogramming to remodel glial scar for spinal cord injury repair.Stem cell research & therapy · 2026Article
- Engineering Silk Fibroin-Based Biomaterials for Neural Repair.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Epigenetic mechanisms of inflammatory memory in the central nervous system.Nature immunology · 2026Review
- Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting.Nature reviews. Immunology · 2026Review
- Transcription initiation profiling defines the regulatory logic of astrocyte gene regulation.bioRxiv : the preprint server for biology · 2026Article
- Persistent homology-based multiscale Hi-C analysis uncovers TADs-mediated gene regulation.Scientific reports · 2026Article
- Astrocyte-driven immunosuppression in the brain tumor microenvironment.Nature immunology · 2026Review
- Astrocyte Functional Heterogeneity in Multiple Sclerosis.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Curing the brain: in search for new astrocyte-specific therapies.Experimental & molecular medicine · 2026Review
- Superenhancer-mediated ferroptosis in age-related hearing loss: cochlear epigenomics.Cellular and molecular life sciences : CMLS · 2026Article
- NF-κB activation in astrocytes impairs wound healing after traumatic brain injury in male mice.Nature communications · 2026Article
- Phagocytosis and neuroinflammation: orchestrating central nervous system homeostasis, repair, and the resolution of inflammation.Trends in neurosciences · 2026Review
- The rise of astrocytes: are they guardians or troublemakers of the brain disorder?Experimental & molecular medicine · 2026Review
- Regional Molecular Diversity in Chronic Spinal Cord Injury.Cellular and molecular neurobiology · 2026Article
- Article
- Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 2 institutions in 2 countries.
Joshua E Burda *Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. Joshua.Burda@csmc.edu.ORCID http://orcid.org/0000-0001-5139-348X
Timothy M O'Shea *Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Yan AoDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Keshav B SureshDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Shinong WangDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Alexander M BernsteinDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Ashu ChandraDepartment of Computer Science, University of California Los Angeles, Los Angeles, CA, USA.
Sandeep DeverasettyDepartment of Psychiatry, University of California Los Angeles, Los Angeles, CA, USA.
Riki KawaguchiDepartment of Psychiatry, University of California Los Angeles, Los Angeles, CA, USA.
Jae H KimDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-1027-8845
Sarah McCallumDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2156-3219
Alexandra RogersDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4675-6968
Shalaka WahaneDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3795-6407
Michael V SofroniewDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. sofroniew@mednet.ucla.edu.ORCID http://orcid.org/0000-0001-6075-0178
University of California, Los Angeles · USCedars-Sinai Medical Center · US
Funding
UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARLEY IAN KORNBLUM · 2020 to 2026
$9.6MInjectable biomaterial depots to manipulate scar and foster axon growth after SCIR01NS084030 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOFRONIEW, MICHAEL V · 2014 to 2023
$3.0MAstrocyte Regulation of Neural Plasticity After CNS InjuryR00NS105915 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI BURDA, JOSHUA EVAN · 2019 to 2021
$739kAstrocyte regulation of neural plasticity after CNS injuryK99NS105915 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BURDA, JOSHUA EVAN · 2018 to 2019
$186kAstrocyte regulation of intraspinal plasticity and spontaneous recovery after SCIF32NS096858 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BURDA, JOSHUA EVAN · 2016 to 2017
$119kNICHD NIH HHS P50 HD103557NINDS NIH HHS F32 NS096858NINDS NIH HHS K99 NS105915NINDS NIH HHS R00 NS105915NINDS NIH HHS R01 NS084030
Abstract
Astrocytes respond to injury and disease in the central nervous system with reactive changes that influence the outcome of the disorder
Indexed as
AstrocytesCentral Nervous System DiseasesGene Expression RegulationTranscription FactorsTranscription, GeneticAnimalsChromatinHigh-Throughput Nucleotide SequencingHumansMiceSequence Analysis, RNAChromatinTranscription Factors
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.