ArticleNature2022
Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 155 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 2 pooled it
22.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
155 citing papers in PubMed, 2 syntheses or guidelines pooled it, 284 citations in OpenAlex.
- Exosomes orchestrate immune homeostasis in acute ischemia-reperfusion flap injury and chronic wounds: the TLR4/NF-κB-STAT3 R-ratio balance decision model, engineering optimization and translational clinical strategy.Frontiers in immunology · 2026Pooled it
- A systematic review and meta-analysis of the prevalence of tick-borne SFGR in China from 2000 to 2022.PLoS neglected tropical diseases · 2024Pooled it
- From RCT to mechanistic study: ATRA reverses myofibroblast activation by reprogramming glucose metabolism via HIC1 and PCK1/2 to attenuate hypertrophic scar formation.Military Medical Research · 2026Trial
- Sprayable bioadhesive microcarriers loaded with Tβ4-Engineered ADSC exosomes for diabetic wound healing.Bioactive materials · 2026Article
- An ultrasound-switchable hydrogel enables sequential antibacterial and anti-inflammatory therapy for infected diabetic wounds.iScience · 2026Article
- Injection site dictates the immune response to a biodegradable polymer and corresponding collagen regeneration.Bioactive materials · 2026Article
- A proximity ligation screen identifies SNAT2 as a novel target of the MARCH1 E3 ubiquitin ligase.Biology open · 2026Article
- Ferroptosis in T cells: mechanisms, biology and translational opportunities.Nature reviews. Immunology · 2026Review
- Single-cell transcriptomics-guided dynamic hydrogel delivery of artemisia argyi-derived EVs relieves ER stress and promotes diabetic wound regeneration.Journal of nanobiotechnology · 2026Article
- 4-Octyl Itaconate Promotes Diabetic Wound Healing by Enhancing Pro-Resolving Macrophages via the Efferocytosis-MCT1-Lactate-GPR132 Pathway and Macrophage-Independent Synergistic Effects.Diabetes & metabolism journal · 2026Article
- 4-Octyl Itaconate Promotes Diabetic Wound Healing by Enhancing Pro-Resolving Macrophages via the Efferocytosis-MCT1-Lactate-GPR132 Pathway and Macrophage-Independent Synergistic Effects (Diabetes Metab J 2026;50:707-23).Diabetes & metabolism journal · 2026Article
- Off‑the‑shelf, engineered non-living stem cell strategy for advancing cellular therapies.Nature biomedical engineering · 2026Article
- Human adipose-derived mesenchymal stem cells ameliorate Diabetic Kidney Disease by restoring macrophage efferocytosis.Stem cell research & therapy · 2026Article
- HIF-1α attenuates ferroptosis-associated dermal fibroblast senescence via modulation of NF-κB-DPP4 signaling.Journal of translational medicine · 2026Article
- Dynamically responsive hydrogel with mechanical stimulation enhances diabetic wound healing via activation of Piezo1-mediated efferocytosis.Bioactive materials · 2026Article
- Diabetes and Delayed Wound Healing: Molecular Mechanisms and Dermatological Interventions.International wound journal · 2026Review
- Inflammation and wound healing: a comprehensive overview of mechanisms, therapeutic strategies, and translational perspectives.Biomarker research · 2026Review
- Neutrophil-guided pro-efferocytic mRNA platform for accelerated diabetic wound repair.Journal of nanobiotechnology · 2026Article
- Macrophage efferocytosis promotes inflammation resolution and accelerates wound healing.Communications biology · 2026Review
- Versatile DNA Hydrogel-Mediated Delivery of Ginsenoside-Encapsulated Small Extracellular Vesicles to Boost Diabetic Wound Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
13 authors at 5 institutions in 2 countries.
Sophia MaschalidiUnit for Cell Clearance in Health and Disease, VIB Center for Inflammation Research, Ghent, Belgium. sophia.maschalidi@irc.vib-ugent.be.ORCID http://orcid.org/0000-0002-8245-8925
Parul Mehrotra *Unit for Cell Clearance in Health and Disease, VIB Center for Inflammation Research, Ghent, Belgium.
Burcu N Keçeli *Unit for Cell Clearance in Health and Disease, VIB Center for Inflammation Research, Ghent, Belgium.
Hannah K L De CleeneUnit for Cell Clearance in Health and Disease, VIB Center for Inflammation Research, Ghent, Belgium.ORCID http://orcid.org/0000-0002-3466-0643
Kim LecomteDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0001-8402-9799
Renée Van der CruyssenDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Pauline JanssenLaboratory of Neuro-Aging and Viro-Immunotherapy, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.
Jonathan PinneyThe Center for Cell Clearance, University of Virginia, Charlottesville, VA, USA.
Geert van LooDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-8427-4775
Dirk ElewautDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-7468-974X
Ann MassieLaboratory of Neuro-Aging and Viro-Immunotherapy, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0002-8418-5879
Esther HosteDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-3181-431X
Kodi S RavichandranUnit for Cell Clearance in Health and Disease, VIB Center for Inflammation Research, Ghent, Belgium. kodi@wustl.edu.ORCID http://orcid.org/0000-0001-9049-1410
Ghent University · BEGhent University Hospital · BEVrije Universiteit Brussel · BEUniversity College Ghent · BEUniversity of Virginia · US
Funding
Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A., RAVICHANDRAN, KODI S · 2014 to 2023
$24.0MSolute carrier proteins in efferocytosis and inflammationR01AI159551 · NIAID · WASHINGTON UNIVERSITY · PI RAVICHANDRAN, KODI S · 2021 to 2025
$2.9MMechanisms regulating apoptotic cell clearance in health and diseaseR35GM122542 · NIGMS · WASHINGTON UNIVERSITY · PI RAVICHANDRAN, KODI S · 2017 to 2021
$2.3MEuropean Research CouncilNHLBI NIH HHS P01 HL120840NIAID NIH HHS R01 AI159551NIGMS NIH HHS R35 GM122542
Abstract
Chronic non-healing wounds are a major complication of diabetes, which affects 1 in 10 people worldwide. Dying cells in the wound perpetuate the inflammation and contribute to dysregulated tissue repair
Indexed as
Amino Acid Transport System y+Dendritic CellsDiabetes MellitusPhagocytosisWound HealingAnimalsGluconeogenesisGlucoseGlycolysisGrowth Differentiation Factor 15MiceAmino Acid Transport System y+Gdf15 protein, mouseGlucoseGrowth Differentiation Factor 15Slc7a11 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.