Evidence map›Paper›PMID 35613930›Full record

ArticleNeurology2022

Genetic Risk, Midlife Life's Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study.

Adrienne Tin, Jan Bressler, Jeannette Simino, Kevin J Sullivan, Hao Mei, B Gwen Windham, Michael Griswold, Rebecca F Gottesman, Eric Boerwinkle, Myriam Fornage and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Associations of plasma HDL subclasses with incident dementia risk in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Association between unhealthy lifestyles and young-onset dementia: a nationwide cohort study.European archives of psychiatry and clinical neuroscience · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Life's Essential 8 and midlife trajectories in cognition and brain health: The CARDIA study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Physical activity changes during midlife link to brain integrity and amyloid burden.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Cardiovascular health, infection burden, and incident dementia in the UK Biobank.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Adrienne TinFrom the Memory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine (A.T., K.J.S., B.G.W., M.G., T.H.M.) and Department of Data Science (J.S., H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (A.T.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Human Genetics Center, School of Public Health (J.B., E.B., M.F.), and Institute of Molecular Medicine, McGovern Medical School (M.F.), University of Texas Health Science Center at Houston; and Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Program, National Institutes of Health, Bethesda, MD. atin@umc.edu.ORCID 0000-0002-4207-5866
Jan BresslerFrom the Memory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine (A.T., K.J.S., B.G.W., M.G., T.H.M.) and Department of Data Science (J.S., H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (A.T.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Human Genetics Center, School of Public Health (J.B., E.B., M.F.), and Institute of Molecular Medicine, McGovern Medical School (M.F.), University of Texas Health Science Center at Houston; and Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Program, National Institutes of Health, Bethesda, MD.
Jeannette SiminoFrom the Memory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine (A.T., K.J.S., B.G.W., M.G., T.H.M.) and Department of Data Science (J.S., H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (A.T.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Human Genetics Center, School of Public Health (J.B., E.B., M.F.), and Institute of Molecular Medicine, McGovern Medical School (M.F.), University of Texas Health Science Center at Houston; and Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Program, National Institutes of Health, Bethesda, MD.
Kevin J SullivanFrom the Memory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine (A.T., K.J.S., B.G.W., M.G., T.H.M.) and Department of Data Science (J.S., H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (A.T.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Human Genetics Center, School of Public Health (J.B., E.B., M.F.), and Institute of Molecular Medicine, McGovern Medical School (M.F.), University of Texas Health Science Center at Houston; and Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Program, National Institutes of Health, Bethesda, MD.
Hao MeiFrom the Memory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine (A.T., K.J.S., B.G.W., M.G., T.H.M.) and Department of Data Science (J.S., H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (A.T.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Human Genetics Center, School of Public Health (J.B., E.B., M.F.), and Institute of Molecular Medicine, McGovern Medical School (M.F.), University of Texas Health Science Center at Houston; and Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Program, National Institutes of Health, Bethesda, MD.
B Gwen WindhamFrom the Memory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine (A.T., K.J.S., B.G.W., M.G., T.H.M.) and Department of Data Science (J.S., H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (A.T.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Human Genetics Center, School of Public Health (J.B., E.B., M.F.), and Institute of Molecular Medicine, McGovern Medical School (M.F.), University of Texas Health Science Center at Houston; and Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Program, National Institutes of Health, Bethesda, MD.
Michael GriswoldFrom the Memory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine (A.T., K.J.S., B.G.W., M.G., T.H.M.) and Department of Data Science (J.S., H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (A.T.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Human Genetics Center, School of Public Health (J.B., E.B., M.F.), and Institute of Molecular Medicine, McGovern Medical School (M.F.), University of Texas Health Science Center at Houston; and Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Program, National Institutes of Health, Bethesda, MD.
Rebecca F GottesmanFrom the Memory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine (A.T., K.J.S., B.G.W., M.G., T.H.M.) and Department of Data Science (J.S., H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (A.T.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Human Genetics Center, School of Public Health (J.B., E.B., M.F.), and Institute of Molecular Medicine, McGovern Medical School (M.F.), University of Texas Health Science Center at Houston; and Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Program, National Institutes of Health, Bethesda, MD.
Eric BoerwinkleFrom the Memory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine (A.T., K.J.S., B.G.W., M.G., T.H.M.) and Department of Data Science (J.S., H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (A.T.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Human Genetics Center, School of Public Health (J.B., E.B., M.F.), and Institute of Molecular Medicine, McGovern Medical School (M.F.), University of Texas Health Science Center at Houston; and Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Program, National Institutes of Health, Bethesda, MD.
Myriam FornageFrom the Memory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine (A.T., K.J.S., B.G.W., M.G., T.H.M.) and Department of Data Science (J.S., H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (A.T.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Human Genetics Center, School of Public Health (J.B., E.B., M.F.), and Institute of Molecular Medicine, McGovern Medical School (M.F.), University of Texas Health Science Center at Houston; and Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Program, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-0677-8158
Thomas H MosleyFrom the Memory Impairment and Neurodegenerative Dementia (MIND) Center and Department of Medicine (A.T., K.J.S., B.G.W., M.G., T.H.M.) and Department of Data Science (J.S., H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (A.T.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Human Genetics Center, School of Public Health (J.B., E.B., M.F.), and Institute of Molecular Medicine, McGovern Medical School (M.F.), University of Texas Health Science Center at Houston; and Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Program, National Institutes of Health, Bethesda, MD.
National Institutes of Health · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Therapeutic target discovery in ADSP data via comprehensive whole-genome analysis incorporating ethnic diversity and systems approachesU01AG058589 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOERWINKLE, ERIC A., DE JAGER, PHILIP L · 2018 to 2022
$11.1M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOTTESMAN, REBECCA F · 2022 to 2025
$8.2M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)RF1AG059421 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2018 to 2018
$6.1M
NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS P30 AG066546NIA NIH HHS RF1 AG059421NIA NIH HHS U01 AG052409NIA NIH HHS U01 AG058589
6 · The paper itself

Abstract

BACKGROUND AND

objectivesHigher scores in Life's Simple 7 (LS7), a metric for cardiovascular and brain health, have been associated with lower risk of dementia. It is uncertain whether this association holds among those with high genetic risk of dementia. Our objective is to evaluate the extent that LS7 may offset dementia risk across the range of genetic risk.

methodsParticipants in the Atherosclerosis Risk in Communities (ARIC) Study were followed from 1987-1989 to 2019. We derived midlife LS7 scores and generated genetic risk scores (GRS) using genome-wide summary statistics of Alzheimer disease, which have been used to study the genetic risk for dementia. Incident dementia was ascertained based on the criteria of the National Institute on Aging-Alzheimer's Association workgroups and Diagnostic and Statistical Manual of Mental Disorders. The associations of the GRS and LS7 with incident dementia were evaluated using Cox regression.

resultsThis study included 8,823 European American (EA) and 2,738 African American (AA) participants (mean age at baseline 54 years). We observed 1,603 cases of dementia among EA participants and 631 among AA participants (median follow-up 26.2 years). Higher GRS were associated with higher risk of dementia (EA, hazard ratio [HR] per SD 1.44, 95% CI 1.37, 1.51; AA, HR 1.26, 95% CI 1.16, 1.36). Among EA participants, higher LS7 scores were consistently associated with lower risk of dementia across quintiles of GRS, including the highest quintile (HR per point 0.91, 95% CI 0.87, 0.96). Among AA participants, the associations between LS7 and incident dementia within stratum of GRS had the same direction as among EA participants, although wide CIs and smaller sample sizes limited reliable inferences. DISCUSSION: Across strata of GRS, higher midlife LS7 scores were associated with lower risk of dementia. Larger sample sizes from diverse populations are needed to obtain more reliable estimates of the effects of modifiable health factors on dementia risk within genetic risk strata in each ancestry group.

Indexed as

AtherosclerosisCardiovascular DiseasesDementiaBlack or African AmericanHumansMiddle AgedRisk Factors

Identifiers

PMID35613930
PMCPMC9280991
OpenAlexW4281562950

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.