ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Role of Sleep in Formation of Relational Associative Memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- No evidence for the impact of mind wandering on recognition associative task: an on-line preregistered study.Psychological research · 2026Article
- Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Human tau pathology is associated with lonely, nontraveling slow waves linked to memory impairment.Nature neuroscience · 2026Article
- Sleep patterns and short-term memory performance among Saudi university students: a structural equation modelling approach.Cognitive processing · 2026Article
- Hippocampal indexing alters the stability landscape of synaptic weight space allowing life-long learning.bioRxiv : the preprint server for biology · 2025Article
- Memory reactivation during rest forms shortcuts in a cognitive map.Scientific reports · 2025Article
- A unified framework to model synaptic dynamics during the sleep-wake cycle.PLoS biology · 2025Article
- Local versus global sleep organization and the quest to determine sleep function.Neurobiology of sleep and circadian rhythms · 2025Article
- Sleep and quiet wakefulness signify an idling brain hub for creative insights.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Augmenting hippocampal-prefrontal neuronal synchrony during sleep enhances memory consolidation in humans.Nature neuroscience · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Relational memory, the ability to make and remember associations between objects, is an essential component of mammalian reasoning. In relational memory tasks, it has been shown that periods of offline processing, such as sleep, are critical to making indirect associations. To understand biophysical mechanisms behind the role of sleep in improving relational memory, we developed a model of the thalamocortical network to test how slow-wave sleep affects performance on an unordered relational memory task. First, the model was trained in the awake state on a paired associate inference task, in which the model learned to recall direct associations. After a period of subsequent slow-wave sleep, the model developed the ability to recall indirect associations. We found that replay, during sleep, of memory patterns learned in awake increased synaptic connectivity between neurons representing the item that was overlapping between tasks and neurons representing the unlinked items of the different tasks; this forms an attractor that enables indirect memory recall. Our study predicts that overlapping items between indirectly associated tasks are essential for relational memory, and sleep can reactivate pathways to and from overlapping items to the unlinked objects to strengthen these pathways and form new relational memories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.