Evidence map›Paper›PMID 35613821›Full record

ArticleBMJ open2022

SARS-CoV-2 RBD-specific and NP-specific antibody response of healthcare workers in the westernmost Austrian state Vorarlberg: a prospective cohort study.

Michele Atzl, Axel Muendlein, Thomas Winder, Peter Fraunberger, Eva-Maria Brandtner, Kathrin Geiger, Miriam Klausberger, Mark Duerkop, Lukas Sprenger, Beatrix Mutschlechner and 7 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Michele AtzlDepartment of Internal Medicine II, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
Axel MuendleinVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.
Thomas WinderDepartment of Internal Medicine II, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
Peter FraunbergerMedical Central Laboratories, Feldkirch, Austria.
Eva-Maria BrandtnerVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.
Kathrin GeigerVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.
Miriam KlausbergerDepartment of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Wien, Austria.
Mark DuerkopDepartment of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Wien, Austria.
Lukas SprengerDepartment of Internal Medicine II, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
Beatrix MutschlechnerDepartment of Internal Medicine II, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
Andreas VolggerDepartment of Internal Medicine II, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
Magdalena BendaDepartment of Internal Medicine II, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
Luciano SevergniniDepartment of Internal Medicine II, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
Johannes B JaegerDepartment of Internal Medicine II, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.
Heinz DrexelVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.
Alois LangAgency for Preventive and Social Medicine, Bregenz, Austria.
Andreas LeihererVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria andreas.leiherer@vivit.at.ORCID 0000-0003-3776-5704
Landeskrankenhaus Feldkirch · ATVorarlberg Institute for Vascular Investigation and Treatment · ATBOKU University · ATPrivate University in the Principality of Liechtenstein · LIIVF Centers Prof. Zech · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAustria, and particularly its westernmost federal state Vorarlberg, developed an extremely high incidence rate during the COVID-19 pandemic. Healthcare workers (HCWs) worldwide are known to have an increased risk of contracting the disease within the working environment and, therefore, the seroprevalence in this population is of particular interest. We thus aimed to analyse SARS-CoV-2-specific antibody dynamics in Vorarlberg HCWs.

designProspective cohort study of HCWs including testing at three different time points for the prevalence of anti-SARS-CoV-2 IgG antibodies specific for nucleocapsid protein (NP) and receptor-binding domain (RBD).

settingAll five state hospitals of Vorarlberg.

participantsA total of 395 HCWs, enrolled in June 2020 (time point 1 (t MAIN OUTCOMES: We assessed weak and strong seropositivity and associated factors, including demographic and clinical characteristics, symptoms consistent with COVID-19 infection, infections verified by reverse transcription PCR (RT-PCR) and vaccinations.

resultsAt t CONCLUSION AND RELEVANCE: Serological testing based on only one antigen implicates the risk of missing infections; thus, the set of antigens should be broadened in the future. The seroprevalence among participating HCWs was comparable to the general population in Austria. Nevertheless, in view of undetected infections, monitoring and surveillance should be reconsidered.

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralAntibody FormationAustriaHealth PersonnelHumansImmunoglobulin GNucleocapsid ProteinsPandemicsProspective StudiesSeroepidemiologic StudiesAntibodies, ViralImmunoglobulin GNucleocapsid Proteinsclinical chemistryCOVID-19epidemiologyinfection controloccupational & industrial medicinepublic health

Identifiers

PMID35613821
PMCPMC9174531
OpenAlexW4281476109

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.