Observational studyBMJ open2022
Trends in bacterial sepsis incidence and mortality in France between 2015 and 2019 based on National Health Data System (Système National des données de Santé (SNDS)): a retrospective observational study.
Observational study in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Sex and gender considerations in randomized controlled trials in critical care nephrology: a meta-epidemiologic study.BMC medicine · 2025Pooled it
- Corticosteroids for treating sepsis in children and adults.The Cochrane database of systematic reviews · 2025Pooled it
- The impact of community-acquired critical sepsis on long-term mortality and morbidity-a nationwide cohort study.Scientific reports · 2026Article
- Early discontinuation of antibiotic therapy initiated in the emergency department in older patients: a retrospective study.BMC geriatrics · 2026Observational
- Rising rates of sepsis in England: an ecological study.Infection · 2025Article
- Liberation and discharge status of older patients after invasive mechanical ventilation: a retrospective cohort study.BMC geriatrics · 2025Article
- Impacts of the COVID-19 pandemic on sepsis incidence, etiology and hospitalization costs in France: a retrospective observational study.BMC infectious diseases · 2025Observational
- Population Sepsis Incidence, Mortality, and Trends in Hong Kong Between 2009 and 2018 Using Clinical and Administrative Data.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- The impact of early morphine administration on septic patients with pre-existing chronic heart failure.Clinics (Sao Paulo, Brazil) · 2025Article
- Reassessing sepsis research: new clues for old players and new players for an old symptom to improve patient outcomes.EXCLI journal · 2025Review
- Targeting Sepsis: Disease Tolerance, Immune Resilience, and Compartmentalized Immunity.Biomedicines · 2024Review
- Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark.Pediatric nephrology (Berlin, Germany) · 2024Article
- Sepsis in Latvia-Incidence, Outcomes, and Healthcare Utilization: A Retrospective, Observational Study.Healthcare (Basel, Switzerland) · 2024Article
- Survival prediction for heart failure complicated by sepsis: based on machine learning methods.Frontiers in medicine · 2024Article
- Trends in mortality after a sepsis hospitalization: a nationwide prospective registry study from 2008 to 2021.Infection · 2023Article
- Economic burden of in-hospital AKI: a one-year analysis of the nationwide French hospital discharge database.BMC nephrology · 2023Article
- Care pathways of sepsis survivors: sequelae, mortality and use of healthcare services in France, 2015-2018.Critical care (London, England) · 2023Article
- One-year hospital readmission for recurrent sepsis: associated risk factors and impact on 1-year mortality-a French nationwide study.Critical care (London, England) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to provide a case definition of sepsis of presumed bacterial aetiology based on 10th revision of the International Classification of Diseases (ICD-10) codes, to assess trends in sepsis incidence and mortality between 2015 and 2019 in France, and to describe the characteristics of affected patients and hospital stays.
designNationwide, population-based, retrospective observational study.
settingMetropolitan France between 2015 and 2019.
participantsBetween 2015 and 2019, 1 224 433 patients with sepsis of presumed bacterial aetiology were selected from the French National Hospital Discharge Database (Programme de Médicalisation des Systèmes d'Information) and were identified from corresponding ICD-10 codes for explicit sepsis or implicit sepsis. MAIN OUTCOMES MEASURES: Annual overall and age-specific and gender-specific incidence and 95% CI, as well as trends in sepsis incidence and mortality, were estimated. Comorbidities, length of hospital stay and outcomes were described.
resultsThe sex-standardised and age-standardised incidence per 100 000 (95% CI) increased from 357 (356.0 to 359.0) in 2015 to 403 (401.9 to 405.0) in 2019 and remained higher for males compared with females. Children under 1 year and patients over 75 years consistently had the highest incidence. The most common comorbidities were cancer and chronic heart failure. The median hospital length of stay was 12 days. Most patients came from home, but only half returned home after their hospital stay and approximately 15% were discharged to long-term care. In-hospital mortality was about 25% and declined along the study period.
conclusionsMedico-administrative databases can be used to provide nationwide estimates of the in-hospital burden of bacterial sepsis. The results confirm the high burden of sepsis in France. These data should be complemented by estimating the additional burden associated with fungal and viral infections during the COVID-19 pandemic.
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