ArticleEnvironmental research2022
Prenatal organophosphorus pesticide exposure and executive function in preschool-aged children in the Norwegian Mother, Father and Child Cohort Study (MoBa).
Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The role of cytochrome P450 genetic variants in pesticide metabolism and the risk of child neurodevelopment: a systematic review.Frontiers in pediatrics · 2025Pooled it
- Joint associations between gestational environmental chemical mixtures and child behavioral outcomes.Environment international · 2026Article
- Pesticides, an urgent challenge to global environmental health and planetary boundaries.Frontiers in toxicology · 2025Review
- Organophosphorus pesticide exposure from house dust and parent-reported child behavior in Latino children from an orchard community.Neurotoxicology · 2024Article
- Predictors of executive function among 2 year olds from a Thai birth cohort.Infant behavior & development · 2024Article
- Exploring the link between the pediatric exposome, respiratory health, and executive function in children: a narrative review.Frontiers in public health · 2024Review
- Maternal pesticide exposure and risk of birth defects: a population-based cross-sectional study in China.Frontiers in public health · 2024Article
- Organophosphorus Pesticide Exposure at 17 Weeks' Gestation and Odds of Offspring Attention-Deficit/Hyperactivity Disorder Diagnosis in the Norwegian Mother, Father, and Child Cohort Study.International journal of environmental research and public health · 2022Article
- Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss.Frontiers in public health · 2022Review
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionPrenatal exposure to organophosphorus pesticides (OPPs) has been associated with neurodevelopmental deficits in children, however evidence linking OPPs with specific cognitive mechanisms, such as executive function (EF), is limited.
objectiveThis study aims to evaluate the association between prenatal exposure to OPPs with multiple measures of EF in preschool-aged children, while considering the role of variant alleles in OPP metabolism genes.
methodsWe included 262 children with preschool attention-deficit/hyperactivity disorder (ADHD), and 78 typically developing children, from the Preschool ADHD substudy of the Norwegian, Mother, Father, and Child Cohort Study. Participants who gave birth between 2004 and 2008 were invited to participate in an on-site clinical assessment when the child was approximately 3.5 years; measurements of EF included parent and teacher rating on Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P), and three performance-based assessments. We measured OPP metabolites in maternal urines collected at ∼17 weeks' gestation to calculate total dimethyl- (ΣDMP) and diethyl phosphate (ΣDEP) metabolite concentrations. We estimated multivariable adjusted β's and 95% confidence intervals (CIs) corresponding to a change in z-score per unit increase in log-ΣDMP/DEP. We further characterized gene-OPP interactions for maternal variants in PON1 (Q192R, M55L), CYP1A2 (1548T > C), CYP1A1 (IntG > A) and CYP2A6 (-47A > C).
resultsPrenatal OPP metabolite concentrations were associated with worse parent and teacher ratings of emotional control, inhibition, and working memory. A one log-∑DMP increase was associated with poorer teacher ratings of EF on the BRIEF-P (e.g. emotional control domain: β = 0.55, 95% CI: 0.35, 0.74), when weighted to account for sampling procedures. We found less consistent associations with performance-based EF assessments. We found some evidence of modification for PON1 Q192R and CYP2A6 -47A > C. Association with other variants were inconsistent.
conclusionsBiomarkers of prenatal OPP exposure were associated with more adverse teacher and parent ratings of EF in preschool-aged children.
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