ArticleCell reports2022
Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program.
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Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
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Who cites it
46 citing papers in PubMed, 46 citations in OpenAlex.
- Cytotoxic CX3CR1+ Vδ1 T cells clonally expand in an interplay of CMV, microbiota, and HIV-1 persistence in people on antiretroviral therapy.PLoS pathogens · 2025Trial
- Article
- γδ T cells and cancer.The Journal of clinical investigation · 2026Review
- T Cell Thoughts.Immunological reviews · 2026Review
- γδ T cells show distinct responses to CMV after stem cell transplantation.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Killer-cell immunoglobulin-like receptors define a potent effector program in human γδ T cells.JCI insight · 2026Article
- Effector Vδ1 γδ T cells mediate anti-tumor immunity and are reprogrammed by imatinib in human gastrointestinal stromal tumor.Research square · 2026Article
- CXCR3 signaling promotes Delta One T cell recruitment and antitumor efficacy in colorectal cancer.Journal for immunotherapy of cancer · 2026Article
- Vδ1 T cells exhibit high lactic acid resistance and antitumor activity in solid tumors.Journal of translational medicine · 2026Article
- Role of Donor Unrestricted T Cells (DURTs) in TB Host Defense: Implications for Novel TB Vaccine Development.Vaccines · 2026Review
- Cytotoxic Vδ2+ T cell subsets expand in response to malaria in human tonsil and spleen organoids.PLoS pathogens · 2026Article
- Innate-like T Cell Biology in the Tumor Microenvironment Implications for Cancer Immunotherapy.Cells · 2026Review
- TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function.Science immunology · 2026Article
- Exacerbation of Anti-Cytomegalovirus Immunity and Mobilization of γ9δ1 T Cells During the Acute Phase of Hepatitis E Virus Infection.Microbiology and immunology · 2026Article
- Auguries of adaptivity: LES γδ TCR ligand recognition revisited.Trends in immunology · 2026Review
- BCG vaccination induces antibacterial effector functions among Vδ1/3 T cells that are associated with protection against tuberculosis.Cell reports. Medicine · 2026Article
- Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma.Journal for immunotherapy of cancer · 2026Article
- A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells.Molecular cancer · 2026Article
- Immunophenotyping, activation, and expansion of gamma delta T cells: flow cytometry profiling andFrontiers in immunology · 2026Review
- Pre-existing activation states shape functional heterogeneity of human Vγ9Vδ2 T cells.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
20 authors at 10 institutions in 5 countries.
Jack L McMurrayInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
Anouk von BorstelInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Taher E TaherInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
Eleni SyrimiInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK; Department of Haematology, Birmingham Children's Hospital, Birmingham B4 6NH, UK.
Graham S TaylorInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
Maria SharifInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
Jamie RossjohnInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.
Ester B M RemmerswaalDepartment of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Frederike J BemelmanRenal Transplant Unit, Division of Internal Medicine, Academic Medical Centre, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Felipe A Vieira BragaWellcome Sanger Institute, Cambridge, UK.
Xi ChenWellcome Sanger Institute, Cambridge, UK.
Sarah A TeichmannWellcome Sanger Institute, Cambridge, UK; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge CB10 1SD, UK.
Fiyaz MohammedInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
Andrea A BerryCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Kirsten E LykeCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Kim C WilliamsonDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Michael J T StubbingtonWellcome Sanger Institute, Cambridge, UK.
Martin S DaveyInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia. Electronic address: martin.davey@monash.edu.
Carrie R WillcoxInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: c.r.willcox@bham.ac.uk.
Benjamin E WillcoxInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: b.willcox@bham.ac.uk.
University of Birmingham · GBWellcome Sanger Institute · GBAmsterdam University Medical Centers · NLUniversity of Maryland, Baltimore · USAustralian Regenerative Medicine Institute · AUAustralian Research Council · AUBirmingham Children's Hospital · GBDiscovery Institute · USEuropean Bioinformatics Institute · GBUniformed Services University of the Health Sciences · US
Funding
Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUNNING HOTOPP, JULIE · 2014 to 2023
$36.5MA Systems Biology Approach to Malaria ImmunityU01AI110852 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI WILLIAMSON, KIM C · 2016 to 2019
$2.8MThe impact of in utero HIV exposure on infant T and B cell responses in MalawiU01HD092308 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI CAIRO, CRISTIANA, LAUFER, MIRIAM K. · 2017 to 2021
$2.7MA Systems Biology Approach to Malaria ImmunityR01AI110852 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI WILLIAMSON, KIM C · 2015 to 2015
$778kNIAID NIH HHS R01 AI110852NIAID NIH HHS U01 AI110852NIAID NIH HHS U19 AI110820NICHD NIH HHS U01 HD092308Wellcome TrustWellcome Trust 099266/Z/12/ZWellcome Trust 221725/Z/20/Z
Abstract
γδ T cells are generally considered innate-like lymphocytes, however, an "adaptive-like" γδ compartment has now emerged. To understand transcriptional regulation of adaptive γδ T cell immunobiology, we combined single-cell transcriptomics, T cell receptor (TCR)-clonotype assignment, ATAC-seq, and immunophenotyping. We show that adult Vδ1
Indexed as
Receptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsAdultCD8-Positive T-LymphocytesCell DifferentiationChild, PreschoolGranzymesHumansGranzymesReceptors, Antigen, T-Cell, gamma-deltaadaptiveclonal expansionCP: ImmunologyCP: MicrobiologydifferentiationeffectornaivepathogenT cell receptortranscription factor
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.