ReviewAdvances in experimental medicine and biology2022
Cardiovascular Diseases and Periodontitis.
Review in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05574231 (A Danish Nationwide Longitudinal Registered Based Study on Prevalence, Treatment Patterns and Disease Trajectories of Periodontitis and Co-morbidities 'PlanPerioMed'), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Danish Nationwide Longitudinal Registered Based Study on Prevalence, Treatment Patterns and Disease Trajectories of Periodontitis and Co-morbidities 'PlanPerioMed'
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Radiomic features and carotid stenosis in periodontitis a two stage bootstrap and multimodal machine learning study.Scientific reports · 2026Article
- The ROOT-CTRCD study: exploring the relationship of oral health to cancer therapy-related cardiac dysfunction in HER2-positive breast cancer patients.Cardio-oncology (London, England) · 2026Article
- Severe Periodontitis is Associated With Recurrent Cardiovascular Events-A 10-Year Longitudinal Cohort Study.Journal of periodontal research · 2025Article
- Mesenchymal stem cell-derived apoptotic vesicles: emerging cell-free strategy for periodontitis treatment.Journal of nanobiotechnology · 2025Review
- A Systematic Review of Clinical and Experimental Periodontitis Studies Demonstrating the Expression of PPAR-Gamma: A Meta-Analysis and Bioinformatics Approach.Biomedicines · 2025Review
- Screening for Systemic Diseases Associated with Dental Self-Care in Japanese Adolescents.Journal of clinical medicine · 2024Article
- More than just teeth: How oral health can affect the heart.American heart journal plus : cardiology research and practice · 2024Review
- Bibliometric analysis of the association between periodontal disease and cardiovascular disease.Heliyon · 2024Article
- Plasmon resonance biosensor for interleukin-1β point-of-care determination: A tool for early periodontitis diagnosis.iScience · 2024Article
- Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients.Open medicine (Warsaw, Poland) · 2024Review
- The increasing importance of the oral microbiome in periodontal health and disease.Future science OA · 2023Review
- Mechanisms Underlying the Suppression of IL-1β Expression by Magnesium Hydroxide Nanoparticles.Biomedicines · 2023Article
- A Comparative Study of Periodontal Health Status between International and Domestic University Students in Japan.International journal of environmental research and public health · 2023Article
- Periodontitis may predict the use of prescription medicines later in life, a database study.Frontiers in pharmacology · 2023Article
- Oral Health in Japan: State-of-the-Art and Perspectives.International journal of environmental research and public health · 2022Article
- [Latest Research Findings on the Mechanism of Periodontal Pathogens in Cardiovascular Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- The impact of periodontitis on vascular endothelial dysfunction.Frontiers in cellular and infection microbiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is a chronic inflammatory disease of the tooth-supporting connective tissue and alveolar bone that is initiated by a bacterial biofilm in periodontal pockets. It affects about half of adults in the Western world, and is associated with a range of systemic comorbidities, e.g., cardiovascular disease (CVD), diabetes and rheumatoid arthritis, and these diseases share overlapping systemic and target tissue inflammatory mechanisms. Indeed, mounting evidence has indicated that their association is causal and built on the presence of systemic low-grade inflammation (LGI). Prior research linking periodontitis to CVD has mainly been derived from experimental studies, observational data, and small interventional trials with surrogate markers of CVD, e.g., endothelial dysfunction. However, recent data from randomised studies have demonstrated that intensive treatment of periodontitis can reduce blood pressure in patients with hypertension in conjunction with reduction of systemic inflammatory markers. Furthermore, targeted anti-inflammatory therapy has been shown to reduce recurrent events in patients with established CVD and LGI. Along this line, the concept of residual inflammatory risk has emerged as an independent new risk factor for atherothrombotic CVD. The present review summarizes translational evidence indicating that periodontitis is a risk factor for CVD dependent on LGI, and we conclude that treatment of periodontitis is likely to contribute importantly to reduction of residual inflammatory risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.