ArticleAdvances in experimental medicine and biology2022
Update on B Cell Response in Periodontitis.
Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Immunomodulation as a novel treatment strategy for periodontal disease: a systematic review.BMC oral health · 2026Pooled it
- Toll-like receptor engaged in activation and osteoimmuno-cytokines production by unswitched memory B cells during periodontitis.Odontology · 2026Article
- Evaluation of Immunohistochemical Biomarkers in Diabetic Wistar Rats with Periodontal Disease.Journal of personalized medicine · 2024Article
- Exploratory research on the probable shared molecular mechanism and transcription factors between chronic periodontitis and chronic obstructive pulmonary disease.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2023Article
- Periodontal Inflamed Surface Area (PISA) associates with composites of salivary cytokines.PloS one · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B cells have a central and dual role in the physio-pathological mechanisms of periodontitis. They take part in the elimination of the periodontal germs, the induction of tissue destructions and the regulation of the immune response. B cells play an essential role in the destruction of alveolar bone in periodontitis by immunomodulation, rather than by production of antibodies. In the periodontal cell network, B cells are in constant interaction with other immune cells and mesenchymal cells. Periodontitis is characterized by a cellular conversion from a dominant T-cell lesion to a dominant B-cell lesion, particularly enriched in plasma cells. This evolution results from abnormal interactions between B and T cells in periodontitis. Moreover, B cells are at the crossroads of the immune and the bone systems and are involved in the autoimmune mechanisms described in periodontitis. Different subsets of B cells are involved in periodontal destruction, in particular memory B cells, plasma cells and B1 cells. Effector memory B cells strongly express mRANKL in periodontitis and constitute the precursors of plasma cells. B1 cells are also involved in tissue destruction but also in the mechanisms of regulation, in particular via the natural secretion of IL-10 by CD11b
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.