Evidence map›Paper›PMID 35612687›Full record

ArticleInternational ophthalmology2022

Autologous simple conjunctival epithelial transplantation for primary pterygium.

Emilio Pedrotti, Marina Bertolin, Adriano Fasolo, Erika Bonacci, Francesca Bosello, Diego Ponzin, Giorgio Marchini

Abstract read
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Z-shaped incision without epithelial resection in pterygium surgery.International journal of ophthalmology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Emilio Pedrotti *Ophthalmology Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, P.le L.A. Scuro 1, 37134, Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-9535-1131
Marina Bertolin *Research Unit, The Veneto Eye Bank Foundation (Fondazione Banca degli Occhi del Veneto), Pad. G. Rama, Via Paccagnella 11, 30174, Venezia, Italy.ORCID http://orcid.org/0000-0002-6941-8419
Adriano FasoloOphthalmology Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, P.le L.A. Scuro 1, 37134, Verona, Verona, Italy. adriano.fasolo@yahoo.it.ORCID http://orcid.org/0000-0003-2202-7477
Erika BonacciOphthalmology Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, P.le L.A. Scuro 1, 37134, Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-3184-3444
Francesca BoselloOphthalmology Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, P.le L.A. Scuro 1, 37134, Verona, Verona, Italy.ORCID http://orcid.org/0000-0003-0082-2197
Diego PonzinResearch Unit, The Veneto Eye Bank Foundation (Fondazione Banca degli Occhi del Veneto), Pad. G. Rama, Via Paccagnella 11, 30174, Venezia, Italy.ORCID http://orcid.org/0000-0002-6038-3977
Giorgio MarchiniOphthalmology Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, P.le L.A. Scuro 1, 37134, Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-4657-3168
University of Verona · ITVeneto Eye Bank Foundation · IT

Funding

the italian ministry of health and the italian ministry of university and research 5 x 1000
6 · The paper itself

Abstract

purposeTo evaluate the feasibility of a new method of conjunctival transplantation to achieve recovery of the normal conjunctival epithelium over the bare sclera after pterygium excision and prevent its recurrence.

methodsAfter excision of the primary pterygium, we performed simple conjunctival epithelial transplantation (SCET) in which we glued an amniotic membrane patch pre-loaded with tiny autologous conjunctival tissue fragments over the scleral defect. Slit-lamp evaluation was performed at 2 and 7-10 days, and then at 1, 3, 6, and 12 months after surgery, together with confocal microscopy at 3, 6, and 12 months.

resultsSurgical excision and SCET for nasal primary pterygium were performed in 6 eyes (6 patients). No graft detachment occurred. An inflammatory granuloma was excised without sequelae in one patient 2 months after surgery. No signs of recurrence or sight-threatening complications were recorded at 12 months, and in vivo confocal microscopy showed progressive expansion of the conjunctival cell population and formation of a clear corneal-conjunctival transition.

conclusionsSCET takes advantage of the ability of the amniotic membrane and conjunctival cells to renew. Outcomes after SCET are comparable to conventional conjunctival flap surgery and can be achieved in less surgical time and with less donor tissue to be removed.

Indexed as

PterygiumConjunctivaFollow-Up StudiesHumansRecurrenceTransplantation, AutologousAdjuvant treatmentConjunctival surgeryPrimary pterygiumRecurrenceSimple conjunctival epithelial transplantation

Identifiers

PMID35612687
OpenAlexW4281487023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.