Evidence map›Paper›PMID 35612625›Full record

ArticleCurrent microbiology2022

Antiviral Activity of Rosmarinic Acid Against Four Serotypes of Dengue Virus.

Ritesh Panchal, Saikat Ghosh, Rajeev Mehla, Jayachandran Ramalingam, Sunil Gairola, Sandeepan Mukherjee, Abhay Chowdhary

Abstract read
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In one paragraph

Article in Current microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ritesh PanchalSchool of Science, Narsee Monjee Institute of Management Studies, Mumbai, India. ritzpanchal88@gmail.com.ORCID http://orcid.org/0000-0002-4115-3500
Saikat GhoshQuality Control, Serum Institute of India Pvt. Ltd., Pune, India.
Rajeev MehlaQuality Control, Serum Institute of India Pvt. Ltd., Pune, India.
Jayachandran RamalingamQuality Control, Serum Institute of India Pvt. Ltd., Pune, India.
Sunil GairolaQuality Control, Serum Institute of India Pvt. Ltd., Pune, India.
Sandeepan MukherjeeDepartment of Virology, Haffkine Institute for Training, Research and Testing, Mumbai, India.
Abhay ChowdharyDepartment of Microbiology, D. Y. Patil School of Medicine, Navi Mumbai, India. abhaychowdhary@yahoo.com.
Serum Institute of India (India) · IND.Y. Patil University · INHaffkine Institute · INNarsee Monjee Institute of Management Studies · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study was undertaken to evaluate the putative antiviral activity of Rosmarinic acid (RA) against four serotypes of dengue virus (DENV). Our previous in silico binding analysis revealed that RA binds strongly to the envelope domain III (EDIII) protein of all four DENV serotypes. We employed an in vitro Biolayer Interferometry-based OCTET™ platform to study the binding interaction of RA with EDIII protein of the four DENV serotypes. Additionally, a functional plaque assay was developed to investigate the potential inhibition of infection of the four DENV serotypes. Using OCTET™, the binding interaction of RA to DENV-EDIII protein of the four DENV serotypes demonstrates interaction which can be arranged in the following order: EDIII-DENV1 (K

Indexed as

DengueDengue VirusAntibodies, ViralAntiviral AgentsCinnamatesDepsidesHumansRosmarinic AcidSerogroupViral Envelope ProteinsAntibodies, ViralAntiviral AgentsCinnamatesDepsidesRosmarinic AcidViral Envelope Proteins

Identifiers

PMID35612625
OpenAlexW4281482825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.