Evidence map›Paper›PMID 35612565›Full record

ArticleMolecular nutrition & food research2022

Maternal Diet Is Associated with Human Milk Oligosaccharide Profile.

Marta Selma-Royo, Sonia González, Miguel Gueimonde, Melinda Chang, Annalee Fürst, Cecilia Martínez-Costa, Lars Bode, Maria Carmen Collado

Abstract read
In one paragraph

Article in Molecular nutrition & food research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
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  12. Diet's impact on gut microbial assemblage in health and disease.The Journal of clinical investigation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marta Selma-RoyoInstitute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), Paterna, Valencia, 46980, Spain.ORCID 0000-0002-4258-947X
Sonia GonzálezDepartment of Functional Biology, University of Oviedo, Oviedo, Asturias, 33006, Spain.ORCID 0000-0003-2602-7036
Miguel GueimondeDiet, Microbiota, and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, 33011, Spain.ORCID 0000-0002-0192-901X
Melinda ChangDepartment of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.
Annalee FürstDepartment of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.
Cecilia Martínez-CostaDepartment of Pediatrics, School of Medicine, University of Valencia, Valencia, 46010, Spain.ORCID 0000-0003-1347-7521
Lars BodeDepartment of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.
Maria Carmen ColladoInstitute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), Paterna, Valencia, 46980, Spain.ORCID 0000-0002-6204-4864

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

scopeHuman milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk. The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown. Thus, this study is aimed to examine the association between maternal diet and HMO profiles. METHODS AND

resultsThis is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers. HMO profiling is assessed by quantitative HPLC. Maternal dietary information is recorded through an FFQ, and perinatal factors including the mode of delivery, antibiotic exposure, and breastfeeding practices, are collected. A more significant effect of diet on HMO profiles is observed in secretor mothers than in non-secretor mothers. (Poly)phenols and fibers, both soluble and insoluble, and several insoluble polysaccharides, pectin, and MUFA are associated with the secretor HMO profiles.

conclusionsMaternal diet is associated with the composition and diversity of HMO in a secretor status-dependent manner. The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.

Indexed as

Milk, HumanOligosaccharidesBreast FeedingChildCross-Sectional StudiesDietFemaleHumansInfantPregnancyOligosaccharidesbreast milkfiberhuman milk oligosaccharidesmaternal dietsecretor

Identifiers

PMID35612565
PMCPMC9541341

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.