ArticleCNS neuroscience & therapeutics2022
Group-based trajectory modeling of intracranial pressure in patients with acute brain injury: Results from multi-center ICUs, 2008-2019.
Article in CNS neuroscience & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 21 citations in OpenAlex.
- Intracranial Pressure and Brain Tissue Oxygen Trajectories after Cardiac Arrest.Neurocritical care · 2026Article
- Hemoglobin Trajectory Phenotypes and Neurological Outcomes in a Neurosurgical ICU Cohort.Journal of clinical medicine · 2026Article
- Association between trajectory of intracranial pressure and all-cause mortality in patients with non-traumatic subarachnoid hemorrhage: A retrospective cohort study from 2008 to 2022.Neurosurgical review · 2026Article
- Association between blood urea nitrogen trajectory phenotypes and prognosis in patients with sepsis: a multicenter retrospective cohort study.BMC infectious diseases · 2026Observational
- Four Distinct Dynamic Intracranial Pressure Trajectories and Their Prognostic Implications in Acute Brain Injury: A Multicenter Cohort Study.CNS neuroscience & therapeutics · 2026Article
- Trajectories of jugular bulb venous oxygen saturation after cardiac arrest are associated with distinct patterns of cerebral pathophysiology.Resuscitation plus · 2025Article
- Intracranial pressure trajectories and functional outcomes in pediatric intracranial hemorrhage: a group-based trajectory modeling analysis.European journal of pediatrics · 2025Article
- Trajectory-based analysis of early mechanical ventilation PEEP levels and physiological parameter trajectories in ARDS patients and their association with the occurrence of gastrointestinal injury events.BMC pulmonary medicine · 2025Article
- Group-Based Trajectory Modeling Identifies Distinct Patterns of Sympathetic Hyperactivity Following Traumatic Brain Injury.Neurocritical care · 2025Observational
- Cerebral perfusion pressure targets after traumatic brain injury: a reappraisal.Critical care (London, England) · 2025Observational
- Influence of age-adjusted shock index trajectories on 30-day mortality for critical patients with septic shock.Frontiers in medicine · 2025Article
- More Physical Exercise is Beneficial to Glycemic Control in Late Pregnancy Among Women with Gestational Diabetes Mellitus: Findings Based on Trajectory Model in a Prospective Cohort in Shanghai.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Effects of 24-hour urine-output trajectories on the risk of acute kidney injury in critically ill patients with cirrhosis: a retrospective cohort analysis.Renal failure · 2024Article
- Group based trajectory modeling identifies distinct patterns of sympathetic hyperactivity following traumatic brain injury.Research square · 2024Article
- Article
- The intracranial compartmental syndrome: a proposed model for acute brain injury monitoring and management.Critical care (London, England) · 2023Review
- Longitudinal hemoglobin trajectories and acute kidney injury in patients undergoing cardiac surgery: a retrospective cohort study.Frontiers in cardiovascular medicine · 2023Article
- Group-based trajectory modeling of intracranial pressure in patients with acute brain injury: Results from multi-center ICUs, 2008-2019.CNS neuroscience & therapeutics · 2022Article
- Assessment of cerebral hemodynamics in patients with acute brain injury: a group-based multivariate trajectory approach.Frontiers in neurologyArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of the study was to characterize the longitudinal, dynamic intracranial pressure (ICP) trajectory in acute brain injury (ABI) patients admitted to intensive care unit (ICU) and explore whether it added sights over traditional thresholds in predicting outcomes.
methodsABI patients with ICP monitoring were identified from two public databases named Medical Information Mart for the Intensive Care (MIMIC)-IV and eICU Collaborative Research Database (eICU-CRD). Group-based trajectory modeling (GBTM) was employed to identify 4-h ICP trajectories in days 0-5 post-ICU admission. Then, logistic regression was used to compare clinical outcomes across distinct groups. To further validate previously reported thresholds, we created the receiver operating characteristic (ROC) curve in our dataset.
resultsA total of 810 eligible patients were ultimately enrolled in the study. GBTM analyses generated 6 distinct ICP trajectories, differing in the initial ICP, evolution pattern, and number/proportion of spikes >20/22 mmHg. Compared with patients in "the highest, declined then rose" trajectory, those belonging to the "lowest, stable," "low, stable," and "medium, stable" ICP trajectories were at lower risks of 30-day mortality (odds ratio [OR] 0.04; 95% confidence interval [CI] 0.01, 0.21), (OR 0.04; 95% CI 0.01, 0.19), (OR 0.08; 95% CI 0.01, 0.42), respectively. ROC analysis demonstrated an unfavorable result, for example, 30-day mortality in total cohort: an area under the curve (AUC): 0.528, sensitivity: 0.11, and specificity: 0.94.
conclusionsThis study identified three ICP trajectories associated with elevated risk, three with reduced risks for mortality during ICU hospitalization. Notably, a fixed ICP threshold should not be applied to all kinds of patients. GBTM, a granular method for describing ICP evolution and their association with clinical outcomes, may add to the current knowledge in intracranial hypertension treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.