ArticleHuman brain mapping2022
Abnormal interhemispheric and intrahemispheric functional connectivity dynamics in drug-naïve first-episode schizophrenia patients with auditory verbal hallucinations.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Candidate Multimodal MRI Markers of Persistent Auditory Verbal Hallucinations: A Controlled Pilot Study.Tomography (Ann Arbor, Mich.) · 2026Observational
- Cognitive deficits linked to intrinsic timescales and gray matter volume abnormalities in children with Duchenne muscular dystrophy.Journal of neurodevelopmental disorders · 2026Article
- Decreased Broca-left supplementary motor area connectivity underlying auditory verbal hallucination: A resting-state NIRS study.Translational psychiatry · 2026Article
- Altered inter-hemispheric and intra-hemispheric functional connectivity dynamics in male cigarette smokers.BMC psychiatry · 2025Article
- Cerebral hemodynamic characteristics of patients with auditory verbal hallucinations and the construction of nomogram models.World journal of psychiatry · 2025Article
- Advances in MRI Research for First-Episode Schizophrenia: A Selective Review and NSFC-Funded Analysis.Schizophrenia bulletin · 2025Review
- Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder.Frontiers in psychiatry · 2025Article
- Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder.BMC psychiatry · 2023Article
- Abnormal interhemispheric and intrahemispheric functional connectivity dynamics in drug-naïve first-episode schizophrenia patients with auditory verbal hallucinations.Human brain mapping · 2022Article
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10 authors.
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Abstract
Numerous studies indicate altered static local and long-range functional connectivity of multiple brain regions in schizophrenia patients with auditory verbal hallucinations (AVHs). However, the temporal dynamics of interhemispheric and intrahemispheric functional connectivity patterns remain unknown in schizophrenia patients with AVHs. We analyzed resting-state functional magnetic resonance imaging data for drug-naïve first-episode schizophrenia patients, 50 with AVHs and 50 without AVH (NAVH), and 50 age- and sex-matched healthy controls. Whole-brain functional connectivity was decomposed into ipsilateral and contralateral parts, and sliding-window analysis was used to calculate voxel-wise interhemispheric and intrahemispheric dynamic functional connectivity density (dFCD). Finally, the correlation analysis was performed between abnormal dFCD variance and clinical measures in the AVH and NAVH groups. Compared with the NAVH group and healthy controls, the AVH group showed weaker interhemispheric dFCD variability in the left middle temporal gyrus (p < .01; p < .001), as well as stronger interhemispheric dFCD variability in the right thalamus (p < .001; p < .001) and right inferior temporal gyrus (p < .01; p < .001) and stronger intrahemispheric dFCD variability in the left inferior frontal gyrus (p < .001; p < .01). Moreover, abnormal contralateral dFCD variability of the left middle temporal gyrus correlated with the severity of AVHs in the AVH group (r = -.319, p = .024). The findings demonstrate that abnormal temporal variability of interhemispheric and intrahemispheric dFCD in schizophrenia patients with AVHs mainly focus on the temporal and frontal cortices and thalamus that are pivotal components of auditory and language pathways.
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