ArticleJournal of the Endocrine Society2022
11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome.
Article in Journal of the Endocrine Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Treatment and complications of PCOS in adolescents - what's new in 2023?Frontiers in endocrinology · 2024Pooled it
- Measurement of 11-Oxo-androgens, A Novel Biomarker, in Females with Clinical Signs of Premature AdrenarcheJournal of clinical research in pediatric endocrinology · 2026Article
- The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women.International journal of molecular sciences · 2024Article
- Biomarkers in Polycystic Ovary Syndrome.Current opinion in physiology · 2023Article
- The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review.Metabolites · 2023Review
- Androgen excess: a hallmark of polycystic ovary syndrome.Frontiers in endocrinology · 2023Review
- 11-Oxygenated androgens are not secreted by the human ovary: in-vivo data from four different cases of hyperandrogenism.European journal of endocrinology · 2022Article
- Criteria for Diagnosis of Polycystic Ovary Syndrome during Adolescence: Literature Review.Diagnostics (Basel, Switzerland) · 2022Review
- Case report: 11-ketotestosterone may potentiate advanced bone age as seen in some cases of Wiedemann-Steiner Syndrome.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Context: Polycystic ovary syndrome (PCOS) is common and diagnosis requires an elevated testosterone. The clinical importance of adrenal 11-oxyandrogens in PCOS is unclear. Objective: We sought to determine if 11-oxyandrogens 1) better identify PCOS diagnosis compared to testosterone, 2) predict clinical comorbidities of PCOS, and 3) are altered with an combined oral contraceptive pill (COCP) or metformin therapy. Methods: Data from 200 adolescent female participants aged 12 to 21 years, most with obesity, enrolled across 6 studies in pediatric endocrinology were included: 70 non-PCOS controls, 115 untreated PCOS, 9 PCOS + obesity treated with COCP, and 6 PCOS + obesity treated with metformin. 11-Hydroxyandrostenedione (11-OHA4), 11-hydroxytestosterone (1-OHT), 11-ketotestosterone (11-KT), and testosterone were measured with liquid chromatography-tandem mass spectrometry. Data between 1) untreated PCOS and controls and 2) untreated PCOS and the 2 treatment groups were compared. Results: Untreated girls with PCOS had higher 11-OHA4 ( Conclusion: Although 11-oxyandrogens do not aid in the diagnosis of PCOS, they relate to excess hair growth. COCP treatment may related to 11-KT; however, further work is needed to determine causality, relationship with metabolic outcomes, and the clinical utility of measuring these androgens in PCOS.
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Registered trials
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