Evidence map›Paper›PMID 35611307›Full record

ArticleBrain communications2022

Longitudinal EEG model detects antisense oligonucleotide treatment effect and increased UBE3A in Angelman syndrome.

Elizabeth R Spencer, Wen Shi, Robert W Komorowski, James P Gilbert, Lauren M Ostrowski, Lynne M Bird, Ronald Thibert, Channa Bao, Fiona Molloy, Michael Calhoun and 5 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Remote EEG acquisition in Angelman syndrome using PANDABox-EEG.Journal of neurodevelopmental disorders · 2025
    Article
  9. Clinical trials for Lennox-Gastaut syndrome: Challenges and priorities.Annals of clinical and translational neurology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Natural antisense transcripts as drug targets.Frontiers in molecular biosciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Elizabeth R SpencerDepartment of Mathematics and Statistics, Boston University, 02215 Boston, MA, USA.
Wen ShiDepartment of Neurology, Massachusetts General Hospital, 02114 Boston, MA, USA.
Robert W KomorowskiBiogen Inc, 02142 Cambridge, MA, USA.
James P GilbertBiogen Inc, 02142 Cambridge, MA, USA.
Lauren M OstrowskiDepartment of Neurology, Massachusetts General Hospital, 02114 Boston, MA, USA.
Lynne M BirdDepartment of Pediatrics, University of California, 92093 San Diego, CA, USA.
Ronald ThibertDepartment of Neurology, Massachusetts General Hospital, 02114 Boston, MA, USA.
Channa BaoBiogen Inc, 02142 Cambridge, MA, USA.
Fiona MolloyBiogen Inc, 02142 Cambridge, MA, USA.
Michael CalhounBiogen Inc, 02142 Cambridge, MA, USA.
Samir KoiralaBiogen Inc, 02142 Cambridge, MA, USA.
Paymaan Jafar-NejadIonis Pharmaceuticals, 92010 Carlsbad, CA, USA.
Frank RigoIonis Pharmaceuticals, 92010 Carlsbad, CA, USA.ORCID https://orcid.org/0000-0001-6467-3309
Mark A KramerDepartment of Mathematics and Statistics, Boston University, 02215 Boston, MA, USA.
Catherine J ChuDepartment of Neurology, Massachusetts General Hospital, 02114 Boston, MA, USA.ORCID https://orcid.org/0000-0001-7670-9313
Biogen (United States) · USHarvard University · USBoston University · USIonis Pharmaceuticals (United States) · USUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angelman syndrome is a neurodevelopmental disorder caused by deficiency of the maternally inherited

Indexed as

Angelman syndromeantisense oligonucleotidebiomarkersEEGUBE3A

Identifiers

PMID35611307
PMCPMC9123847
OpenAlexW4224680747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.