Evidence map›Paper›PMID 35610659›Full record

ArticleTrials2022

Intensity matters: protocol for a randomized controlled trial exercise intervention for individuals with chronic stroke.

Lynden Rodrigues, Kevin Moncion, Janice J Eng, Kenneth S Noguchi, Elise Wiley, Bernat de Las Heras, Shane N Sweet, Joyce Fung, Marilyn MacKay-Lyons, Aimee J Nelson and 5 more

2 registry-linked trialsOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03614585 naunknown statusnot on this map

Exercise Intensity Matters: An Opportunity to Promote Neurorecovery and Cardiovascular Health in Stroke

TypeinterventionalSponsorMcGill UniversityRan2020 to 2024Enrolled80ConditionsStrokeArms12 weeks of High-intensity Interval Training, 12 weeks of Moderate-Intensity Continuous Training
NCT07375745 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Combined Gait Training and Transcutaneous Spinal Cord Stimulation to Enhance Lower Limbs Motor Recovery After Subacute SCI

TypeinterventionalSponsorCentre for Interdisciplinary Research in Rehabilitation of Greater MontrealRan2026 to 2029Enrolled40ConditionsSpinal Cord Injury, Spinal Cord Injury Subacute, Locomotion, Gait Disorder, SensorimotorArmsProtocol 1: Gait training combined with a sham stimulation, Protocol 2: Gait training combined with an effective tSCS
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Lynden Rodrigues *School of Physical and Occupational Therapy, McGill University, 3654 Promenade Sir-William-Osler, Québec, Montréal, Canada.
Kevin Moncion *School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
Janice J EngDepartment of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
Kenneth S NoguchiSchool of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
Elise WileySchool of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
Bernat de Las HerasSchool of Physical and Occupational Therapy, McGill University, 3654 Promenade Sir-William-Osler, Québec, Montréal, Canada.
Shane N SweetFeil/Oberfeld/CRIR Research Centre, Jewish Rehabilitation Hospital site of CISSS-Laval, Laval, Québec, Canada.
Joyce FungSchool of Physical and Occupational Therapy, McGill University, 3654 Promenade Sir-William-Osler, Québec, Montréal, Canada.
Marilyn MacKay-LyonsSchool of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada.
Aimee J NelsonDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Diogo MedeirosSchool of Physical and Occupational Therapy, McGill University, 3654 Promenade Sir-William-Osler, Québec, Montréal, Canada.
Jennifer CrozierSchool of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
Alexander ThielDepartment of Neurology & Neurosurgery, McGill University, Montréal, Québec, Canada.
Ada TangSchool of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
Marc RoigSchool of Physical and Occupational Therapy, McGill University, 3654 Promenade Sir-William-Osler, Québec, Montréal, Canada. marc.roigpull@mcgill.ca.ORCID http://orcid.org/0000-0002-1016-467X
McMaster University · CAJewish Rehabilitation Hospital · CADalhousie University · CAMcGill University · CAThe Memory Clinic · USUniversity of British Columbia · CA

Funding

CIHR 388320
6 · The paper itself

Abstract

rationaleCardiovascular exercise is an effective method to improve cardiovascular health outcomes, but also promote neuroplasticity during stroke recovery. Moderate-intensity continuous cardiovascular training (MICT) is an integral part of stroke rehabilitation, yet it may remain a challenge to exercise at sufficiently high intensities to produce beneficial adaptations to neuroplasticity. High-intensity interval training (HIIT) could provide a viable alternative to achieve higher intensities of exercise by using shorter bouts of intense exercise interspersed with periods of recovery. METHODS AND

designThis is a two-arm, parallel-group multi-site RCT conducted at the Jewish Rehabilitation Hospital (Laval, Québec, Canada) and McMaster University (Hamilton, Ontario, Canada). Eighty participants with chronic stroke will be recruited at both sites and will be randomly allocated into a HIIT or MICT individualized exercise program on a recumbent stepper, 3 days per week for 12 weeks. Outcomes will be assessed at baseline, at 12 weeks post-intervention, and at an 8-week follow-up. OUTCOMES: The primary outcome is corticospinal excitability, a neuroplasticity marker in brain motor networks, assessed with transcranial magnetic stimulation (TMS). We will also examine additional markers of neuroplasticity, measures of cardiovascular health, motor function, and psychosocial responses to training. DISCUSSION: This trial will contribute novel insights into the effectiveness of HIIT to promote neuroplasticity in individuals with chronic stroke.

trial registrationClinicalTrials.gov NCT03614585 . Registered on 3 August 2018.

Indexed as

High-Intensity Interval TrainingStrokeStroke RehabilitationExercise TherapyHumansOntarioRandomized Controlled Trials as TopicCardiovascular healthClinical trialExerciseNeuroplasticityStroke

Identifiers

PMID35610659
PMCPMC9127488
OpenAlexW4281387266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.