ReviewCritical care (London, England)2022
Venous return and mean systemic filling pressure: physiology and clinical applications.
Review in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hemodynamic Resuscitation Guided by Non-Invasive Mean Systemic Filling Pressure to Prevent Acute Kidney Injury in Septic Shock: A Randomized Controlled Trial Integrating Renal Doppler Indices
Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial
Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Exploring Pandora's box: a review of thoracic compartment syndrome.Anaesthesiology intensive therapy · 2025Pooled it
- Dynamic Measures of Fluid Responsiveness to Guide Resuscitation in Patients With Sepsis and Septic Shock: A Systematic Review and Meta-Analysis.Critical care explorations · 2025Pooled it
- Haemodynamic effects of selective venoconstriction with centhaquine in spontaneously breathing patients with mixed hypovolaemic-vasodilatory shock.Experimental physiology · 2026Trial
- Effects of intermittent pneumatic compression on the recovery of cardiovascular parameters after repeated sprint exercise.European journal of applied physiology · 2024Trial
- The increase in cardiac output induced by a decrease in positive end-expiratory pressure reliably detects volume responsiveness: the PEEP-test study.Critical care (London, England) · 2023Trial
- Integrated haemodynamic monitoring of fluid responsiveness and fluid tolerance in critical care: from physiology to bedside applications.Journal of clinical monitoring and computing · 2026Review
- Energy, flow and pressure in the cardiovascular system: a narrative review of how the circulation works.Anaesthesia · 2026Review
- Balancing lung recruitment and venous congestion in ARDS: rethinking the systemic effects of PEEP.Intensive care medicine · 2026Article
- Dobutamine, the chronotropic inodilator-venoconstrictor?Intensive care medicine experimental · 2026Article
- Development and validation of a proposed rule for estimating central venous pressure from inferior vena cava dynamics: a clinical prediction model study.Journal of anesthesia, analgesia and critical care · 2026Article
- Effect of intraoperative positioning on anesthetic variables in cats undergoing a perineal urethrostomy.Journal of feline medicine and surgery · 2026Article
- Dynamic indices of fluid responsiveness: physiological basis and clinical limits.Intensive care medicine · 2026Article
- Venous return versus cardiac function: who drives the circulation?Intensive care medicine · 2026Article
- Hidden effects of dobutamine on cardiac output.Intensive care medicine experimental · 2026Article
- Central Venous Pressure Referencing in the Lateral Position: Comparison With Direct Right Atrial Pressure in Mechanically Ventilated ICU Patients.Acta anaesthesiologica Scandinavica · 2026Observational
- Cardiac Tamponade Under Positive-Pressure Ventilation: Pathophysiological Insights and Implications for Diagnosis.Reviews in cardiovascular medicine · 2026Review
- The Geometry of Circulatory Shock: A Conceptual Multi-Scale Lagrangian Framework for Physiology-Informed Hemodynamic Phenotyping.Journal of clinical medicine · 2026Review
- Measuring and managing pulmonary edema in ARDS: a narrative review.Critical care (London, England) · 2026Review
- The effects of vasopressors on initial distribution volume of glucose in pigs.Journal of anesthesia · 2026Article
- Fluid responsiveness and changes in venous congestion and lung water during volume expansion in critically ill patients: a multicentre observational study.Critical care (London, England) · 2026Observational
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Venous return is the flow of blood from the systemic venous network towards the right heart. At steady state, venous return equals cardiac output, as the venous and arterial systems operate in series. However, unlike the arterial one, the venous network is a capacitive system with a high compliance. It includes a part of unstressed blood, which is a reservoir that can be recruited via sympathetic endogenous or exogenous stimulation. Guyton's model describes the three determinants of venous return: the mean systemic filling pressure, the right atrial pressure and the resistance to venous return. Recently, new methods have been developed to explore such determinants at the bedside. In this narrative review, after a reminder about Guyton's model and current methods used to investigate it, we emphasize how Guyton's physiology helps understand the effects on cardiac output of common treatments used in critically ill patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.