Evidence map›Paper›PMID 35610603›Full record

Trial reportBMC psychiatry2022

Physical and mental health outcomes of an integrated cognitive behavioural and weight management therapy for people with an eating disorder characterized by binge eating and a high body mass index: a randomized controlled trial.

Phillipa Hay, Marly Amorim Palavras, Felipe Quinto da Luz, Sérgio Dos Anjos Garnes, Amanda Sainsbury, Stephen Touyz, José Carlos Appolinario, Angélica Medeiros Claudino

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02464345 nacompletednot on this map

A Randomised Controlled Trial of a New Integrated Approach to Management of Eating and Weight Disorders, Namely a Healthy APproach to weIght Management and Food in Eating Disorders Compared to Cognitive Behaviour Therapy Enhanced.

TypeinterventionalSponsorFederal University of São PauloRan2015 to 2019Enrolled98ConditionsBinge Eating Disorder, Bulimia Nervosa, Eating DisorderArmsHAPIFED, CBT-E
NCT05873127 nacompletednot on this mapstarted 2023, after this paper: background citation

A Randomized Controlled Study of Web-based Guided Self-help CBT-E Versus Online Group CBT-E for Binge Eating Behavior

TypeinterventionalSponsorShanghai Mental Health CenterRan2023 to 2026Enrolled120ConditionsFeeding and Eating DisordersArmsweb-based guided self-help Enhanced Cognitive Behavioral therapy, online Enhanced Cognitive Behavioral therapy
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

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  18. Current Discoveries and Future Implications of Eating Disorders.International journal of environmental research and public health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Phillipa HaySchool of Medicine, Translational Health Research Institute, Western Sydney University, 1797 Locked Bag Avenue, Sydney, 2751, Australia. p.hay@westernsydney.edu.au.ORCID 0000-0003-0296-6856
Marly Amorim PalavrasSchool of Medicine, Translational Health Research Institute, Western Sydney University, 1797 Locked Bag Avenue, Sydney, 2751, Australia.ORCID 0000-0001-9367-1628
Felipe Quinto da LuzEating Disorders Program (AMBULIM), Faculty of Medicine, Universidade de São Paulo (USP), Rua Dr. Ovídio Pires de Campos, 785, São Paulo, SP, 05403-010, Brazil.ORCID 0000-0002-2088-4099
Sérgio Dos Anjos GarnesEating Disorders Program (PROATA), Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), Rua Major Maragliano 241, São Paulo, SP, 04017-030, Brazil.
Amanda SainsburySchool of Human Sciences, The University of Western Australia, Perth, 6009, Australia.ORCID 0000-0001-9176-1574
Stephen TouyzInside Out Institute and School of Psychology, Charles Perkins Centre, SLHD and The University of Sydney, Sydney, 2006, Australia.ORCID 0000-0002-1290-6243
José Carlos AppolinarioObesity and Eating Disorders Group - Institute of Psychiatry, Federal University of Rio de Janeiro (UFRJ), Avenida Pedro Calmon 550, Rio de Janeiro, RJ, 21941-901, Brazil.ORCID 0000-0002-6089-4400
Angélica Medeiros ClaudinoEating Disorders Program (PROATA), Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), Rua Major Maragliano 241, São Paulo, SP, 04017-030, Brazil.ORCID 0000-0002-0209-9409
The University of Sydney · AUUniversidade Federal de São Paulo · BRWestern Sydney University · AUThe University of Western Australia · AUUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBulimia nervosa (BN) and binge eating disorder (BED) are eating disorders (EDs) characterized by recurrent binge eating. They are associated with medical complications, impaired adaptive function and often a high BMI, for which a multidisciplinary treatment approach may be needed. This study explored the efficacy of a novel intervention integrating Cognitive Behavioural Therapy- Enhanced (CBT-E) and weight management for people with recurrent binge eating episodes and high BMI with respect to physical, psychopathological and quality of life outcomes.

methodsNinety-eight adults diagnosed with BN, BED, or Other Specified/Unspecified Feeding or Eating Disorder (OSFED/UFED) and BMI ≥ 27 to <40 kg/m

resultsBoth HAPIFED and CBT-E showed statistical significance for the time effect, with reduction in stress (p < 0.001), improvement in mental health-related quality of life (p = 0.032), reduction in binge eating severity (p < 0.001), and also in global ED symptoms scores (p < 0.001), with the significant changes found at end of treatment and sustained at 12-month follow-up. However, no statistical significance was found for differences between the interventions in any of the outcomes measured. Despite a high BMI, most participants (> 75%) had blood test results for glucose, insulin, triglycerides and cholesterol within the normal range, and 52% were within the normal range for the physical component of quality of life at baseline with no change during the trial period.

conclusionIntegrating weight and ED management resulted in comparable outcomes to ED therapy alone. Although adding weight management to an ED intervention had no adverse effects on psychological outcomes, it also had no beneficial effect on metabolic outcomes. Therefore, more intense weight management strategies may be required where indicated to improve metabolic outcomes. Safety will need to be concurrently investigated.

trial registrationUS National Institutes of Health clinical trial registration number NCT02464345 , date of registration 08/06/2015. Changes to the present paper from the published protocol paper (Trials 18:578, 2015) and as reported in the Trial registration (clinicaltrials.gov) are reported in Supplementary File 1.

Indexed as

Binge-Eating DisorderBulimiaBulimia NervosaFeeding and Eating DisordersAdultBody Mass IndexCognitionHumansOutcome Assessment, Health CareQuality of LifeBinge-eating disorderBulimia nervosaQuality of lifeTherapyWeight loss

Identifiers

PMID35610603
PMCPMC9131673
OpenAlexW4281383033

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.