Evidence map›Paper›PMID 35610602›Full record

ArticleBMC pulmonary medicine2022

B cell subsets were associated with prognosis in elderly patients with community acquired pneumonia.

Chun-Mei Wang, Ying Zhang, Hui-Hui Xu, Fang-Jie Huo, Yin-Zhen Li, Zhi-Fang Li, Hong-Qiang Li, Si-Ting Liu, Xiao-Ming Zhang, Jian-Wen Bai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Chun-Mei Wang *Department of Emergency Medicine and Critical Care, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Pudong New District, Shanghai, 200120, China.
Ying Zhang *Department of Emergency Medicine and Critical Care, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Pudong New District, Shanghai, 200120, China.
Hui-Hui XuKey Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, No. 320 Yueyang Road, Xuhui District, Shanghai, 200031, China.
Fang-Jie HuoXi'an No. 4 Hospital, Xi'an, 710004, China.
Yin-Zhen LiDepartment of Emergency Medicine and Critical Care, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Pudong New District, Shanghai, 200120, China.
Zhi-Fang LiDepartment of Emergency Medicine and Critical Care, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Pudong New District, Shanghai, 200120, China.
Hong-Qiang LiDepartment of Emergency Medicine and Critical Care, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Pudong New District, Shanghai, 200120, China.
Si-Ting LiuDepartment of Emergency Medicine and Critical Care, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Pudong New District, Shanghai, 200120, China.
Xiao-Ming ZhangKey Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, No. 320 Yueyang Road, Xuhui District, Shanghai, 200031, China. xmzhang@ips.ac.cn.
Jian-Wen BaiDepartment of Emergency Medicine and Critical Care, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Pudong New District, Shanghai, 200120, China. baijianwen1019@163.com.
Shanghai East Hospital · CNInstitut Pasteur of Shanghai · CNNanjing Medical University · CNUniversity of Chinese Academy of Sciences · CNWuhan No. 7 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of B cell subsets remained to be elucidated in a variety of immune diseases, though which was used as an effective biomarker for anti-inflammatory or antiviral response. This study aimed to evaluate the early changes of B cell subtypes distribution in elderly patients with community acquired pneumonia (CAP), as well as the association between B cell subtypes and prognosis.

methodsThis prospective study included elderly patients with CAP, severe CAP (sCAP) and healthy elderly subjects between April 2016 and March 2018. Flow cytometry was used to detect CD3, CD20, HLA-DR, CD24, CD27, CD38, IgM, and IgD. CD20

resultsA total of 22 healthy controls, 87 patients with CAP and 58 patients with sCAP were included in the study. Compared to CAP, sCAP was characterized by significantly lower absolute number of B cells, Bn and Btr, significantly lower Btr and Bn subset percentage, while percentage of IgM

conclusionsSeverity and prognosis of CAP in elderly people is accompanied by changes in the B cell subsets. Btr subsets could play prognostic role for a short-term mortality of elderly CAP patients.

Indexed as

B-Lymphocyte SubsetsCommunity-Acquired InfectionsPneumoniaAgedHumansImmunoglobulin MPrognosisProspective StudiesRetrospective StudiesROC CurveImmunoglobulin MAgedB-lymphocyte subsetsB-lymphoid precursor cellsCommunity acquired pneumoniaPrognosis

Identifiers

PMID35610602
PMCPMC9128775
OpenAlexW4281395170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.