ArticleScientific reports2022
Association between climate variables and pulmonary tuberculosis incidence in Brunei Darussalam.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 19 citations in OpenAlex.
- Climate Change and the Impact On Interstitial Lung Diseases.Pulmonary therapy · 2026Review
- Spatiotemporal epidemiology and associated risk factors of tuberculosis incidence and mortality in Indonesia 2017-2022: a nationwide space-time hierarchical analysis.Population health metrics · 2026Article
- Burden on the burdened: tuberculosis among Scheduled Tribes and non-Scheduled Tribes in constitutionally protected Scheduled and non-Scheduled areas of India.Infectious diseases of poverty · 2025Article
- Epidemic trend and spatial-temporal analysis of pulmonary tuberculosis in Hotan prefecture, xinjiang, china, 2015-2021.Scientific reports · 2025Article
- Health system and environmental factors affecting global progress towards achieving End TB targets between 2015 and 2020.Journal of global health · 2025Article
- Association of ambient temperature with tuberculosis incidence in Japan: An ecological study.IJID regions · 2024Article
- An investigation of the effects of meteorological factors on the incidence of tuberculosis.Scientific reports · 2024Article
- Ecological-level factors associated with tuberculosis incidence and mortality: A systematic review and meta-analysis.PLOS global public health · 2024Article
- Climate change and respiratory disease: clinical guidance for healthcare professionals.Breathe (Sheffield, England) · 2023Review
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the association between climate variables and pulmonary tuberculosis (PTB) incidence in Brunei-Muara district, Brunei Darussalam. Weekly PTB case counts and climate variables from January 2001 to December 2018 were analysed using distributed lag non-linear model framework. After adjusting for long-term trend and seasonality, we observed positive but delayed relationship between PTB incidence and minimum temperature, with significant adjusted relative risk (adj.RR) at 25.1 °C (95th percentile) when compared to the median, from lag 30 onwards (adj.RR = 1.17 [95% Confidence Interval (95% CI): 1.01, 1.36]), suggesting effect of minimum temperature on PTB incidence after 30 weeks. Similar results were observed from a sub-analysis on smear-positive PTB case counts from lag 29 onwards (adj.RR = 1.21 [95% CI: 1.01, 1.45]), along with positive and delayed association with total rainfall at 160.7 mm (95th percentile) when compared to the median, from lag 42 onwards (adj.RR = 1.23 [95% CI: 1.01, 1.49]). Our findings reveal evidence of delayed effects of climate on PTB incidence in Brunei, but with varying degrees of magnitude, direction and timing. Though explainable by environmental and social factors, further studies on the relative contribution of recent (through primary human-to-human transmission) and remote (through reactivation of latent TB) TB infection in equatorial settings is warranted.
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