Evidence map›Paper›PMID 35610351›Full record

ArticleMolecular psychiatry2022

Generation of human A9 dopaminergic pacemakers from induced pluripotent stem cells.

Hong Li, Houbo Jiang, Hanqin Li, Li Li, Zhen Yan, Jian Feng

Open access · bronzeAbstract read
In one paragraph

Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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  16. Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons.International journal of molecular sciences · 2023
    Article
  17. [Directed differentiation of human induced pluripotent stem cells into midbrain].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hong Li *Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, 14203, USA.
Houbo Jiang *Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, 14203, USA.
Hanqin LiDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, 14203, USA.
Li LiDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, 14203, USA.
Zhen YanDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, 14203, USA.ORCID http://orcid.org/0000-0002-3519-9596
Jian FengDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, 14203, USA. jianfeng@buffalo.edu.ORCID http://orcid.org/0000-0001-7630-8800
University at Buffalo, State University of New York · USVA Western New York Healthcare System · US

Funding

Molecular Segregation of Parkinson’s Disease by Patient-Derived NeuronsR01NS113763 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FENG, JIAN · 2020 to 2024
$2.6M
Functions of parkin in Parkinson’s diseaseR01NS102148 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FENG, JIAN · 2018 to 2021
$1.8M
Functions of parkin in Parkinson’s diseaseR56NS102148 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FENG, JIAN · 2017 to 2017
$399k
The Interaction of parkin and environmental toxins in Parkinson’s diseaseI01BX003831 · VA · VA WESTERN NEW YORK HEALTHCARE SYSTEM · PI FENG, JIAN · 2018 to 2021
–
BLRD VA I01 BX003831NINDS NIH HHS R01 NS102148NINDS NIH HHS R01 NS113763NINDS NIH HHS R56 NS102148
6 · The paper itself

Abstract

The degeneration of nigral (A9) dopaminergic (DA) neurons causes motor symptoms in Parkinson's disease (PD). We use small-molecule compounds to direct the differentiation of human induced pluripotent stem cells (iPSCs) to A9 DA neurons that share many important properties with their in vivo counterparts. The method generates a large percentage of TH

Indexed as

Induced Pluripotent Stem CellsParkinson DiseaseAnimalsDopamineDopaminergic NeuronsHumansOxidopamineRatsSubstantia NigraDopamineOxidopamine

Identifiers

PMID35610351
PMCPMC9684358
OpenAlexW4282922342

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.