Evidence map›Paper›PMID 35610255›Full record

ArticleNature communications2022

Anoctamin 1 controls bone resorption by coupling Cl

Weijia Sun, Shuai Guo, Yuheng Li, JianWei Li, Caizhi Liu, Yafei Chen, Xuzhao Wang, Yingjun Tan, Hua Tian, Cheng Wang and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Tamsulosin ameliorates bone loss by inhibiting the release of ClProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. CaInternational journal of molecular sciences · 2023
    Review
  17. Journal of personalized medicine · 2023
    Article
  18. Article
  19. CaCell calcium · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 1 country.

Weijia Sun *State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 100094, Beijing, China.
Shuai Guo *Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, China.ORCID 0000-0002-5342-9666
Yuheng Li *State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 100094, Beijing, China.
JianWei LiState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 100094, Beijing, China.
Caizhi LiuState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 100094, Beijing, China.
Yafei ChenKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, China.ORCID 0000-0001-7792-5317
Xuzhao WangKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, China.ORCID 0000-0001-6278-0346
Yingjun TanState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 100094, Beijing, China.
Hua TianDepartment of Orthopedics /Engineering Research Center of Bone and Joint Precision Medicine /Beijing Key Laboratory of Spinal Disease Research, Peking University the Third Hospital, 100191, China, Beijing.
Cheng WangDepartment of Orthopedics /Engineering Research Center of Bone and Joint Precision Medicine /Beijing Key Laboratory of Spinal Disease Research, Peking University the Third Hospital, 100191, China, Beijing.
Ruikai DuState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 100094, Beijing, China.
Guohui ZhongState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 100094, Beijing, China.
Sai ShiKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, China.
Biao MaKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, China.
Chang QuKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, China.
Jingxuan FuKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, China.
Xiaoyan JinState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 100094, Beijing, China.
Dingsheng ZhaoState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 100094, Beijing, China.
Yong ZhanKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, China.
Shukuan LingState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 100094, Beijing, China. sh2ling@126.com.ORCID 0000-0002-4622-4160
Hailong AnKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, China. hailong_an@hebut.edu.cn.ORCID 0000-0001-7947-357X
Yingxian LiState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 100094, Beijing, China. yingxianli@aliyun.com.ORCID 0000-0002-5440-3281
China Astronaut Research and Training Center · CNHebei University of Technology · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoclast over-activation leads to bone loss and chloride homeostasis is fundamental importance for osteoclast function. The calcium-activated chloride channel Anoctamin 1 (also known as TMEM16A) is an important chloride channel involved in many physiological processes. However, its role in osteoclast remains unresolved. Here, we identified the existence of Anoctamin 1 in osteoclast and show that its expression positively correlates with osteoclast activity. Osteoclast-specific Anoctamin 1 knockout mice exhibit increased bone mass and decreased bone resorption. Mechanistically, Anoctamin 1 deletion increases intracellular Cl

Indexed as

Bone ResorptionOsteoporosisAnimalsAnoctamin-1FemaleHumansMiceMice, Inbred C57BLNFATC Transcription FactorsOsteoclastsOsteogenesisOvariectomyRANK LigandANO1 protein, mouseAnoctamin-1NFATC Transcription FactorsRANK Ligand

Identifiers

PMID35610255
PMCPMC9130328
OpenAlexW4281390311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.