Evidence map›Paper›PMID 35610217›Full record

ArticleNature communications2022

Off-season RSV epidemics in Australia after easing of COVID-19 restrictions.

John-Sebastian Eden, Chisha Sikazwe, Ruopeng Xie, Yi-Mo Deng, Sheena G Sullivan, Alice Michie, Avram Levy, Elena Cutmore, Christopher C Blyth, Philip N Britton and 16 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 219 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 1 pooled it
49.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 1 synthesis or guideline pooled it, 326 citations in OpenAlex.

  1. Determining the timing of respiratory syncytial virus (RSV) epidemics: a systematic review, 2016 to 2021; method categorisation and identification of influencing factors.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Pooled it
  2. Safety and Immunogenicity of Bivalent RSVpreF Vaccine Coadministered With Seasonal Inactivated Influenza Vaccine in Older Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Trial
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159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 11 institutions in 2 countries.

John-Sebastian Eden *Centre for Virus Research, Westmead Institute for Medical Research, Westmead, NSW, 2145, Australia.ORCID 0000-0003-1374-3551
Chisha Sikazwe *PathWest Laboratory Medicine WA, Department of Microbiology, Nedlands, WA, 6009, Australia.
Ruopeng Xie *School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Yi-Mo DengWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.
Sheena G SullivanWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.ORCID 0000-0002-0856-0294
Alice MichieSchool of Biomedical Sciences, The University of Western Australia, Crawley, WA, 6009, Australia.
Avram LevyPathWest Laboratory Medicine WA, Department of Microbiology, Nedlands, WA, 6009, Australia.
Elena CutmoreCentre for Virus Research, Westmead Institute for Medical Research, Westmead, NSW, 2145, Australia.
Christopher C BlythPathWest Laboratory Medicine WA, Department of Microbiology, Nedlands, WA, 6009, Australia.
Philip N BrittonSydney Institute for Infectious Diseases, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.
Nigel CrawfordMurdoch Children's Research Institute, Melbourne, VIC, 3000, Australia.
Xiaomin DongWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.
Dominic E DwyerSydney Institute for Infectious Diseases, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0002-7163-2844
Kimberly M EdwardsSchool of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.ORCID 0000-0003-0944-3118
Bethany A HorsburghCentre for Virus Research, Westmead Institute for Medical Research, Westmead, NSW, 2145, Australia.
David FoleyPathWest Laboratory Medicine WA, Department of Microbiology, Nedlands, WA, 6009, Australia.ORCID 0000-0002-8622-7809
Karina KennedyDepartments of Clinical Microbiology and Infectious Diseases, Canberra Hospital, Garran, ACT, 2605, Australia.
Cara Minney-SmithPathWest Laboratory Medicine WA, Department of Microbiology, Nedlands, WA, 6009, Australia.
David SpeersPathWest Laboratory Medicine WA, Department of Microbiology, Nedlands, WA, 6009, Australia.
Rachel L TullochCentre for Virus Research, Westmead Institute for Medical Research, Westmead, NSW, 2145, Australia.
Edward C HolmesSydney Institute for Infectious Diseases, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0001-9596-3552
Vijaykrishna DhanasekaranSchool of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. veej@hku.hk.ORCID 0000-0003-3293-6279
David W SmithPathWest Laboratory Medicine WA, Department of Microbiology, Nedlands, WA, 6009, Australia. David.Smith@health.wa.gov.au.ORCID 0000-0002-3107-5182
Jen KokNSW Health Pathology - Institute for Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, 2145, Australia. jen.kok@health.nsw.gov.au.ORCID 0000-0002-8796-283X
Ian G BarrWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia. ian.barr@influenzacentre.org.ORCID 0000-0002-7351-418X
Australian RSV study group
The University of Sydney · AUThe Royal Melbourne Hospital · AUThe University of Western Australia · AUHKU-Pasteur Research Pole · HKPathwest Laboratory Medicine · AURoyal Children's Hospital · AUWestmead Hospital · AUThe Kids Research Institute Australia · AUCanberra Hospital · AUMurdoch Children's Research Institute · AUNew South Wales Department of Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human respiratory syncytial virus (RSV) is an important cause of acute respiratory infection with the most severe disease in the young and elderly. Non-pharmaceutical interventions and travel restrictions for controlling COVID-19 have impacted the circulation of most respiratory viruses including RSV globally, particularly in Australia, where during 2020 the normal winter epidemics were notably absent. However, in late 2020, unprecedented widespread RSV outbreaks occurred, beginning in spring, and extending into summer across two widely separated regions of the Australian continent, New South Wales (NSW) and Australian Capital Territory (ACT) in the east, and Western Australia. Through genomic sequencing we reveal a major reduction in RSV genetic diversity following COVID-19 emergence with two genetically distinct RSV-A clades circulating cryptically, likely localised for several months prior to an epidemic surge in cases upon relaxation of COVID-19 control measures. The NSW/ACT clade subsequently spread to the neighbouring state of Victoria and to cause extensive outbreaks and hospitalisations in early 2021. These findings highlight the need for continued surveillance and sequencing of RSV and other respiratory viruses during and after the COVID-19 pandemic, as mitigation measures may disrupt seasonal patterns, causing larger or more severe outbreaks.

Indexed as

COVID-19Respiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsAgedHumansInfantPandemicsSeasonsVictoria

Identifiers

PMID35610217
PMCPMC9130497
OpenAlexW4281401684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.