Evidence map›Paper›PMID 35610046›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Interactions between Brainstem Neurons That Regulate the Motility to the Stomach.

Lorenza Bellusci, Selena N Garcia DuBar, Michelle Kuah, David Castellano, Vinona Muralidaran, Elizabeth Jones, Aaron M Rozeboom, Richard A Gillis, Stefano Vicini, Niaz Sahibzada

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Molecular cell types as functional units of the efferent vagus nerve.Seminars in cell & developmental biology · 2024
    Review
  6. Brainstem activation of GABAFrontiers in neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Lorenza BellusciDepartments of Pharmacology and Physiology.
Selena N Garcia DuBarDepartments of Pharmacology and Physiology.ORCID https://orcid.org/0000-0002-4730-2642
Michelle KuahDepartments of Pharmacology and Physiology.
David CastellanoDepartments of Pharmacology and Physiology.
Vinona MuralidaranPathology, Georgetown University Medical Center, Washington, DC 20007.
Elizabeth JonesPathology, Georgetown University Medical Center, Washington, DC 20007.
Aaron M RozeboomPathology, Georgetown University Medical Center, Washington, DC 20007.
Richard A GillisDepartments of Pharmacology and Physiology.
Stefano ViciniDepartments of Pharmacology and Physiology svicin01@georgetown.edu sahibzan@georgetown.edu.ORCID https://orcid.org/0000-0001-8671-5194
Niaz SahibzadaDepartments of Pharmacology and Physiology svicin01@georgetown.edu sahibzan@georgetown.edu.
Czech Academy of Sciences, Institute of Physiology · CZGeorgetown University · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
GABAergic Interneurons Regulate Brainstem Neural CircuitryR01DK117508 · NIDDK · GEORGETOWN UNIVERSITY · PI VICINI, STEFANO · 2018 to 2021
$1.4M
NCI NIH HHS P30 CA051008NIDDK NIH HHS R01 DK117508
6 · The paper itself

Abstract

Activity in the dorsal vagal complex (DVC) is essential to gastric motility regulation. We and others have previously shown that this activity is greatly influenced by local GABAergic signaling, primarily because of somatostatin (SST)-expressing GABAergic neurons. To further understand the network dynamics associated with gastric motility control in the DVC, we focused on another neuron prominently distributed in this complex, neuropeptide-Y (NPY) neurons. However, the effect of these neurons on gastric motility remains unknown. Here, we investigate the anatomic and functional characteristics of the NPY neurons in the nucleus tractus solitarius (NTS) and their interactions with SST neurons using transgenic mice of both sexes. We sought to determine whether NPY neurons influence the activity of gastric-projecting neurons, synaptically interact with SST neurons, and affect end-organ function. Our results using combined neuroanatomy and optogenetic

Indexed as

Brain StemStomachAnimalsFemaleGABAergic NeuronsMaleMiceNeuropeptide YRatsRats, Sprague-DawleySolitary NucleusVagus NerveNeuropeptide YDMV: gastric motilityhindbrainNTSoptogeneticsvagus

Identifiers

PMID35610046
PMCPMC9236295
OpenAlexW4281400621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.