Evidence map›Paper›PMID 35610010›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2022

Effcacy-oriented compatibility for Tianma (), Yanlingcao () and Bingpian () on improving cerebral ischemia stroke by network pharmacology and serum pharmacological methods.

L I Zhiyong, Zhu Na, L I Jianliang, Feng Liang, Jiang Yanyan, L I Caifeng, Lin Ling, Huang Xiulan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

L I ZhiyongPostdoctoral mobile station of environmental biology, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.
Zhu NaPharmacological Department, School of Pharmacy, Minzu University of China, Beijing, 100081, China.
L I JianliangAerosol preparation research center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Feng LiangSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
Jiang YanyanDepartment of Chinese Materia Medica Chemistry, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
L I CaifengAcademician work station, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, China.
Lin LingPharmacological Department, School of Pharmacy, Minzu University of China, Beijing, 100081, China.
Huang XiulanPharmacological Department, School of Pharmacy, Minzu University of China, Beijing, 100081, China.
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the compatibility of Tianma (, TM), Yanlingcao (, YLC) and Bingpian (, BP), and their efficacy in the treatment of cerebral ischemic stroke.

methodsNetwork pharmacology was used to determine the compatibility of TM, YLC, and BP, and their potential mechanism. The middle cerebral artery occlusion (MCAO) rat model was used to evaluate the curative effect of the six combinations of TM, YLC, and BP (TZB1-TZB6) on cerebral ischemia, by using the weight matching method to form. The potential component changes of TM and YLC in the blood and brains of rats were analyzed using ultra performance liquid chromatography-mass spectrometry. Finally, molecular docking linked the results of animal experiments and network pharmacology, determining the potential component contributors of TM and YLC to treating ischemic stroke.

resultsTZB reduced the cerebral infarct volume and protected the nerve cells in MCAO rats. The components of TM and YLC were also identified in the blood and brain homogenate, and BP can facilitate the entry of the components of TM and YLC into the blood and brain. Diosgenin, pennogenin, and gastrodin induced effective binding activities with adenosine receptor a1.

conclusionWe investigate an approach that improves the means of folk prescription combined with multi technology that maybe promote the transformation of Chinese medicinal prescription into component-based Chinese medicine.

Indexed as

Brain IschemiaDrugs, Chinese HerbalIschemic StrokeStrokeAnimalsDisease Models, AnimalHumansInfarction, Middle Cerebral ArteryMolecular Docking SimulationNetwork PharmacologyRatsRats, Sprague-DawleyDrugs, Chinese HerbalAdenosine receptor a1brain ischemiainfarction,middle cerebral arterymolecular docking simulationnetwork pharmacology

Identifiers

PMID35610010
PMCPMC9924670
OpenAlexW4282921052

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.