ArticleAnnals of the rheumatic diseases2022
Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study.
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Article in Annals of the rheumatic diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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21 citing papers in PubMed, 34 citations in OpenAlex.
- Integrative post-GWAS analysis prioritizes immune regulatory pathways and candidate effector signals in systemic lupus erythematosus.Journal of translational autoimmunity · 2026Article
- Special Issue: "Advances in Molecular Research on Autoimmune Diseases, 2nd Edition".International journal of molecular sciences · 2026Article
- Proinflammatory keratinocytes drive a novel mouse model of autoimmunity with systemic and cutaneous lupus erythematosus.Immunity & inflammation · 2026Article
- Immune Cell-specific Genetic Regulation in Graves' Disease: An Integrative Mendelian Randomization Study.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Article
- Taming renal inflammation: signaling pathways and therapeutic advances in lupus nephritis.BMC nephrology · 2025Review
- Tracking clonal dynamics of CD8 T cells and immune dysregulation in progression of systemic lupus erythematosus with nephritis.Experimental & molecular medicine · 2025Article
- Transcriptome-wide association study of alternative polyadenylation identifies susceptibility genes in non-small cell lung cancer.Oncogene · 2025Article
- Review
- Exploring the association between systemic lupus erythematosus and osteonecrosis by Mendelian randomization analysis.Scientific reports · 2025Article
- Big Data Science on T Cell Receptor-mediated Immune Regulation.JMA journal · 2025Review
- scTWAS Atlas: an integrative knowledgebase of single-cell transcriptome-wide association studies.Nucleic acids research · 2025Article
- Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study.International journal of genomics · 2025Article
- Population-specific reference panel improves imputation quality for genome-wide association studies conducted on the Japanese population.Communications biology · 2024Article
- [Analysis of characteristics related to the disease activity of systemic lupus erythematosus and construction of an evaluation model].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Thioredoxin is a metabolic rheostat controlling regulatory B cells.Nature immunology · 2024Article
- Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing.Biological psychiatry · 2024Article
- Differential regulation of the interferon response in systemic lupus erythematosus distinguishes patients of Asian ancestry.RMD open · 2023Article
- CD83 Regulates the Immune Responses in Inflammatory Disorders.International journal of molecular sciences · 2023Review
- Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus.Frontiers in medicine · 2023Review
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Authors and funding
82 authors at 20 institutions in 5 countries.
Xianyong Yin *Department of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Kwangwoo Kim *Department of Biology and Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea.ORCID http://orcid.org/0000-0001-8926-6216
Hiroyuki Suetsugu *Laboratory for Bone and Joint Diseases, RIKEN Center for Medical Sciences, Tokyo, Japan.
So-Young BangDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
Leilei WenDepartment of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Masaru KoidoLaboratory for Statistical and Translational Genetics Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Eunji HaDepartment of Biology and Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea.
Lu LiuDepartment of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Yuma SakamotoLaboratory for Bone and Joint Diseases, RIKEN Center for Medical Sciences, Tokyo, Japan.
Sungsin JoHanyang University Institute for Rheumatology Research, Seoul, South Korea.
Rui-Xue LengDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People's Republic of China.ORCID http://orcid.org/0000-0002-2453-5865
Nao OtomoLaboratory for Bone and Joint Diseases, RIKEN Center for Medical Sciences, Tokyo, Japan.
Young-Chang KwonHanyang University Institute for Rheumatology Research, Seoul, South Korea.
Yujun ShengDepartment of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Nobuhiko SuganoDepartment of Orthopaedic Medical Engineering, Osaka University Graduate School of Medicine, Osaka, Japan.ORCID http://orcid.org/0000-0003-4035-3989
Mi Yeong HwangDivision of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, South Korea.
Weiran LiDepartment of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Masaya MukaiDepartment of Rheumatology & Clinical Immunology, Sapporo City General Hospital, Hokkaido, Japan.
Kyungheon YoonDivision of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, South Korea.
Minglong CaiDepartment of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Kazuyoshi IshigakiLaboratory for Statistical and Translational Genetics Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Won Tae ChungDepartment of Internal Medicine, Dong-A University Hospital, Busan, South Korea.
He HuangDepartment of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Daisuke TakahashiDepartment of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
Shin-Seok LeeDivision of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
Mengwei WangDepartment of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Kohei KarinoDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
Seung-Cheol ShimDivision of Rheumatology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, South Korea.
Xiaodong ZhengDepartment of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Tomoya MiyamuraDepartment of Internal Medicine and Rheumatology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan.
Young Mo KangDivision of Rheumatology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, South Korea.
Dongqing YeDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People's Republic of China.ORCID http://orcid.org/0000-0001-6604-9614
Junichi NakamuraDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID http://orcid.org/0000-0003-4005-8832
Chang-Hee SuhDepartment of Rheumatology, Ajou University School of Medicine, Suwon, South Korea.
Yuanjia TangShanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine (SJTUSM), Shanghai, People's Republic of China.
Goro MotomuraDepartment of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yong-Beom ParkDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Huihua DingShanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine (SJTUSM), Shanghai, People's Republic of China.ORCID http://orcid.org/0000-0002-7530-8953
Takeshi KurodaNiigata University Health Administration Center, Niigata, Japan.
Jung-Yoon ChoeDepartment of Rheumatology, Catholic University of Daegu School of Medicine, Daegu, South Korea.
Chengxu LiDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Hiroaki NiiroDepartment of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Youngho ParkHanyang University Institute for Rheumatology Research, Seoul, South Korea.
Changbing ShenDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, People's Republic of China.
Takeshi MiyamotoDepartment of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Ga-Young AhnDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
Wenmin FeiDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Tsutomu TakeuchiDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0003-1111-8218
Jung-Min ShinDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
Keke LiDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Yasushi KawaguchiInstitute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
Yeon-Kyung LeeDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
Yong-Fei WangDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.ORCID http://orcid.org/0000-0002-1260-6291
Koichi AmanoDepartment of Rheumatology & Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Dae Jin ParkDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
Wanling YangDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.ORCID http://orcid.org/0000-0003-0063-6327
Yoshifumi TadaDepartment of Rheumatology, Faculty of Medicine, Saga University, Saga, Japan.
Yu Lung LauDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
Ken YamajiDepartment of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan.
Zhengwei ZhuDepartment of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Masato ShimizuHokkaido Medical Center for Rheumatic Diseases, Sapporo, Japan.
Takashi AtsumiDepartment of Orthopaedic Surgery, Showa University School of Medicine, Tokyo, Japan.
Akari SuzukiLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Takayuki SumidaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.ORCID http://orcid.org/0000-0002-0311-8472
Koichi MatsudaLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Yuta KochiDepartment of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-8012-5078
Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head
Kazuhiko YamamotoLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.ORCID http://orcid.org/0000-0001-9037-3625
Koichiro OhmuraDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Tae-Hwan KimDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.ORCID http://orcid.org/0000-0002-3542-2276
Sen YangDepartment of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Takuaki YamamotoDepartment of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Bong-Jo KimDivision of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, South Korea.
Nan ShenShanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine (SJTUSM), Shanghai, People's Republic of China.ORCID http://orcid.org/0000-0002-5875-4417
Shiro IkegawaLaboratory for Bone and Joint Diseases, RIKEN Center for Medical Sciences, Tokyo, Japan.
Hye-Soon LeeDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
Xuejun ZhangDepartment of Dermatology and Institute of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Chikashi TeraoLaboratory for Statistical and Translational Genetics Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan chikashi.terao@riken.jp wuhucuiyong@vip.163.com scbae@hanyang.ac.kr.ORCID http://orcid.org/0000-0002-6452-4095
Yong CuiDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, People's Republic of China chikashi.terao@riken.jp wuhucuiyong@vip.163.com scbae@hanyang.ac.kr.
Sang-Cheol BaeDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea chikashi.terao@riken.jp wuhucuiyong@vip.163.com scbae@hanyang.ac.kr.ORCID http://orcid.org/0000-0003-4658-1093
Anhui Medical University · CNHanyang University Seoul Hospital · KRRIKEN Center for Integrative Medical Sciences · JPChina-Japan Friendship Hospital · CNChinese University of Hong Kong · HKKorea National Institute of Health · KRKyushu University · JPHanyang University · KRHokkaido University · JPKeio University · JPKyung Hee University · KRShanghai Jiao Tong University · CNYonsei University · KRAichi Cancer Center · JPAjou University · KRBroad Institute · USChiba University · JPChonnam National University Hospital · KRChungnam National University Hospital · KRCincinnati Children's Hospital Medical Center · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGenome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most loci remain unclear, hampering translation of these genetic discoveries. We aimed to prioritise genes underlying the 110 SLE loci that were identified in the latest East Asian GWAS meta-analysis.
methodsWe built gene expression predictive models in blood B cells, CD4
resultsTWAS identified 171 genes for SLE (p<1.0×10
conclusionsCell-level TWAS in six types of immune cells complemented SLE gene discovery and guided the identification of novel genetic associations. The gene findings shed biological insights into SLE genetic associations.
Indexed as
autoimmunitylupus erythematosus, systemicpolymorphism, genetic
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