ReviewJournal of sleep research2022
Obstructive sleep apnea: transition from pathophysiology to an integrative disease model.
Review in Journal of sleep research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Association between obstructive sleep apnea with recurrent pulmonary embolism: a meta-analysis.Irish journal of medical science · 2026Pooled it
- Effectiveness of aerobic exercise training in patients with obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Pooled it
- Three-dimensional upper airway phenotyping and OSA severity: a CT-based study.European radiology · 2026Article
- Identifying JAK2 and ANXA5 as Key Genes Linking Obstructive Sleep Apnea and Oxidative Stress via Machine Learning and Multilayer Transcriptomic Integration With Functional Validation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Salivary Aldosterone as a Biomarker for Obstructive Sleep Apnea: Diagnostic Performance and the Moderating Role of Mean Arterial Pressure-A Cross-Sectional Study.Clocks & sleep · 2026Article
- Investigation of the "Not Better Explained" Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review.Journal of sleep research · 2026Review
- The Intersection of Cardiology and Sleep Medicine: Impact of Sleep-Disordered Breathing on Heart Failure Outcomes.Journal of clinical medicine · 2026Review
- Sleep-disordered breathing as a risk factor for sarcopenia in the elderly: a narrative review.Sleep & breathing = Schlaf & Atmung · 2026Review
- The Role of Lung Volume, Age, and Body Mass Index in Determining Obstructive Sleep Apnea Severity.Medicina (Kaunas, Lithuania) · 2026Article
- CT and finite element analysis of mandibular advancement device mechanics in a participant with obstructive sleep apnea: a proof-of-concept study.BMC oral health · 2026Article
- Obstructive Sleep Apnea in Critically Ill Patients: A Structured Narrative Review of Prevalence, Diagnostic Barriers, and Clinical Implications in the ICU.Clocks & sleep · 2026Review
- Dysfunctional breathing in patients with moderate and severe obstructive sleep apnea: a cross sectional study.Sleep & breathing = Schlaf & Atmung · 2026Article
- Multi-regional radiomics of obstructive sleep apnea based on synthetic MRI.Respiratory research · 2026Article
- The effect of tongue strength and endurance in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2026Article
- Hyperbaric Oxygen Therapy and Its Physio-Mechanical Effects on Sleep Breathing Disorder: A Systematic Review.Pulmonary therapy · 2026Review
- Serum Perilipin-2 as a Novel Biomarker for Obstructive Sleep Apnea: Association with Hypoxic Burden and Disease Severity.Journal of clinical medicine · 2026Article
- Continuous Positive Airway Pressure Versus Nocturnal Oxygen in Obstructive Sleep Apnea: A Propensity Score Matching Study.Advances in respiratory medicine · 2026Article
- Choroidal Detachment in a Patient on a CPAP Therapy.Case reports in ophthalmological medicine · 2026Article
- [Characterastics and determinants of upper airway collapse in OSA patients with different genioglossus negative pressure reflex patterns during DISE].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Article
- Rehabilitation and therapeutic exercise in obstructive sleep apnea: a perspective beyond the apnea-hypopnea index.Frontiers in medicine · 2026Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnea (OSA) is characterised by recurring episodes of upper airway obstruction during sleep and the fundamental abnormality reflects the inability of the upper airway dilating muscles to withstand the negative forces generated within the upper airway during inspiration. Factors that result in narrowing of the oropharynx such as abnormal craniofacial anatomy, soft tissue accumulation in the neck, and rostral fluid shift in the recumbent position increase the collapsing forces within the airway. The counteracting forces of upper airway dilating muscles, especially the genioglossus, are negatively influenced by sleep onset, inadequacy of the genioglossus responsiveness, ventilatory instability, especially post arousal, and loop gain. OSA is frequently associated with comorbidities that include metabolic, cardiovascular, renal, pulmonary, and neuropsychiatric, and there is growing evidence of bidirectional relationships between OSA and comorbidity, especially for heart failure, metabolic syndrome, and stroke. A detailed understanding of the complex pathophysiology of OSA encourages the development of therapies targeted at pathophysiological endotypes and facilitates a move towards precision medicine as a potential alternative to continuous positive airway pressure therapy in selected patients.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.