ArticleDiabetes & metabolism journal2022
Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study.
Article in Diabetes & metabolism journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Midlife depressive symptoms, smoking status, hypertension, diabetes, dyslipidemia and obesity modify the association of long-term vascular risk factor variability from childhood with midlife cognitive function: The Bogalusa Heart Study.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Global, regional, and national trends in mortality and disability attributable to elevated fasting plasma glucose in Alzheimer disease and other dementias, 1990-2021.Molecular medicine (Cambridge, Mass.) · 2026Article
- Diabetes status, duration and risk of dementia in patients with myocardial infarction.Diabetology & metabolic syndrome · 2025Article
- A Narrative Review: Relationship Between Glycemic Variability and Emerging Complications of Diabetes Mellitus.Biomolecules · 2025Review
- Habit-learning and decision-making circuits are susceptible to glycemic variability in type 2 diabetes: a longitudinal study.Frontiers in neuroscience · 2025Article
- Early Detection of Dementia in Populations With Type 2 Diabetes: Predictive Analytics Using Machine Learning Approach.Journal of medical Internet research · 2024Article
- Increased Risk of Alzheimer's Disease With Glycemic Variability: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Glycated Hemoglobin A1c Time in Range and Dementia in Older Adults With Diabetes.JAMA network open · 2024Article
- Effect of glucose variability on the mortality of adults aged 75 years and over during the first year of the COVID-19 pandemic.BMC geriatrics · 2024Article
- The relationship between diabetes and the dementia risk: a meta-analysis.Diabetology & metabolic syndrome · 2024Review
- Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells.Brain sciences · 2024Review
- Cumulative effect of impaired fasting glucose on the risk of dementia in middle-aged and elderly people: a nationwide cohort study.Scientific reports · 2023Article
- Physiological Mechanisms Inherent to Diabetes Involved in the Development of Dementia: Alzheimer's Disease.Neurology international · 2023Review
- Fasting glucose variability and risk of dementia in Parkinson's disease: a 9-year longitudinal follow-up study of a nationwide cohort.Frontiers in aging neuroscience · 2023Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated whether fasting glucose (FG) variability could predict the risk of dementia.
methodsThis cohort study analyzed data from Koreans with diabetes after at least three health examinations by the Korean National Health Insurance Corporation between 2005 and 2010, which included at least one examination between 2009 and 2010. A total of 769,554 individuals were included, excluding those aged <40 years and those with dementia. FG variability was measured using the variability independent of the mean (FG-VIM). The incidence of dementia was defined by the International Classification of Diseases 10th Revision codes and prescription of anti-dementia medication and was subdivided into Alzheimer's disease (AD) and vascular dementia (VD).
resultsDuring the 6.9-year follow-up, 54,837, 41,032, and 6,892 cases of all-cause dementia, AD, and VD, respectively, were identified. Cox proportional regression analyses showed that as the FG-VIM quartile increased, the risk of dementia serially increased after adjustment for metabolic factors, income status, and diabetes-related characteristics, including the mean FG. Participants in FG-VIM quartile 4 showed a 18%, 19%, and 17% higher risk for all-cause dementia, AD, and VD, respectively, than those in quartile 1; this particularly included non-obese patients with a longer duration of diabetes, high FG levels, dyslipidemia, and those taking glucose-lowering medications. Conversely, the baseline FG status and dementia showed a U-shaped association.
conclusionIncreased FG variability over 5 years can predict the risk of dementia in individuals with diabetes in Korea. This finding was more pronounced in patients with less favorable metabolic profiles.
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