Evidence map›Paper›PMID 35609862›Full record

ArticleFree radical biology & medicine2022

Electron transfer activity of the nanodisc-bound mitochondrial outer membrane protein mitoNEET.

Homyra Tasnim, Huangen Ding

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 66% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Homyra TasnimDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA.
Huangen DingDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA. Electronic address: hding@lsu.edu.
Louisiana State University · US

Funding

Electron transfer activity of mitoNEET and regulation of energy metabolism in mitochondriaR15GM129564 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI DING, HUANGEN · 2018 to 2018
$433k
NIGMS NIH HHS R15 GM129564
6 · The paper itself

Abstract

MitoNEET is the first iron-sulfur protein found in mitochondrial outer membrane. Abnormal expression of mitoNEET in cells has been linked to several types of cancer, type II diabetes, and neurodegenerative diseases. Structurally, mitoNEET is anchored to mitochondrial outer membrane via its N-terminal single transmembrane alpha helix. The C-terminal cytosolic domain of mitoNEET binds a [2Fe-2S] cluster via three cysteine and one histidine residues. It has been shown that mitoNEET has a crucial role in energy metabolism, iron homeostasis, and free radical production in cells. However, the exact function of mitoNEET remains elusive. Previously, we reported that the C-terminal soluble domain of mitoNEET has a specific binding site for flavin mononucleotide (FMN) and can transfer electrons from FMNH

Indexed as

Diabetes Mellitus, Type 2Iron-Sulfur ProteinsElectronsEscherichia coliFlavin MononucleotideHumansMembrane ProteinsMitochondrial ProteinsNADOxidation-ReductionOxygenUbiquinoneFlavin MononucleotideIron-Sulfur ProteinsMembrane ProteinsMitochondrial ProteinsNADOxygenUbiquinoneElectron transfer activityFMNMitochondriamitoNEETNADHNanodisc

Identifiers

PMID35609862
PMCPMC10693299
OpenAlexW4281257394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.