Evidence map›Paper›PMID 35609703›Full record

ArticleThe Science of the total environment2022

A new-type HOCl-activatable fluorescent probe and its applications in water environment and biosystems.

Kun Wang, Yilin Liu, Caiyun Liu, Hanchuang Zhu, Xiwei Li, Miaohui Yu, Lunying Liu, Guoqing Sang, Wenlong Sheng, Baocun Zhu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Science of the total environment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 36 citations in OpenAlex.

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  5. An ESIPT-based ratiometric fluorescent probe for detecting HThe Science of the total environment · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kun WangSchool of Water Conservancy and Environment, University of Jinan, Jinan 250022, China.
Yilin LiuSchool of Water Conservancy and Environment, University of Jinan, Jinan 250022, China.
Caiyun LiuSchool of Water Conservancy and Environment, University of Jinan, Jinan 250022, China. Electronic address: liucaiyun1982072@163.com.
Hanchuang ZhuSchool of Water Conservancy and Environment, University of Jinan, Jinan 250022, China.
Xiwei LiSchool of Water Conservancy and Environment, University of Jinan, Jinan 250022, China.
Miaohui YuBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
Lunying LiuSchool of Water Conservancy and Environment, University of Jinan, Jinan 250022, China.
Guoqing SangSchool of Water Conservancy and Environment, University of Jinan, Jinan 250022, China.
Wenlong ShengBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China. Electronic address: 15618694162@163.com.
Baocun ZhuSchool of Water Conservancy and Environment, University of Jinan, Jinan 250022, China. Electronic address: lcyzbc@163.com.
University of Jinan · CNShandong Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The outbreak and spread of Corona Virus Disease 2019 (COVID-19) has led to a significant increase in the consumption of sodium hypochlorite (NaOCl) disinfectants. NaOCl hydrolyzes to produce hypochlorous acid (HOCl) to kill viruses, which is a relatively efficient chlorine-based disinfectant commonly used in public disinfection. While people enjoy the convenience of NaOCl disinfection, excessive and indiscriminate use of it will affect the water environment and threaten human health. Importantly, HOCl is an indispensable reactive oxygen species (ROS) in human body. Whether its concentration is normal or not is closely related to human health. Excessive production of HOCl in the body contributes to some inflammatory diseases and even cancer. Also, we noticed that the concentration of ROS in cancer cells is about 10 times higher than that in normal cells. Herein, we developed a HOCl-activatable biotinylated dual-function fluorescent probe BTH. For this probe, we introduced biotin on the naphthalimide fluorophore, which increased the water solubility and enabled the probe to aggregate in cancer cells by targeting specific receptor overexpressed on the surface of cancer cell membrane. After reacting to HOCl, the p-aminophenylether moiety of this probe was oxidatively removed and the fluorescence of the probe was recovered. As expected, in the PBS solution with pH of 7.4, BTH could give full play to the performance of detecting HOCl, and it has made achievements in detecting the concentration of HOCl in actual water samples. Besides that, BTH had effectively distinguished between cancer cells and normal cells through a dual-function discrimination strategy, which used biotin to enrich the probe in cancer cells and reacted with overexpressed HOCl in cancer cells. Importantly, this dual-function discrimination strategy could obtain the precision detection of cancer cells, thereby offering assistance for improving the accuracy of early cancer diagnosis.

Indexed as

COVID-19DisinfectantsBiotinFluorescent DyesHumansHypochlorous AcidWaterBiotinDisinfectantsFluorescent DyesHypochlorous AcidWaterBiotinCancer cellsFluorescent probeHypochlorous acidWater samples

Identifiers

PMID35609703
PMCPMC9124045
OpenAlexW4281255581

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.