ArticleAmerican journal of ophthalmology2022
Quantification of Anterior Chamber Cells in Children With Uveitis Using Anterior Segment Optical Coherence Tomography.
Article in American journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Anterior segment optical coherence tomography (AS-OCT) identification of anterior chamber hyper-reflective particles: a meta-analytic approach to methods and metrics.Eye (London, England) · 2026Pooled it
- Detection and Measurement of Hypopyon on Slit Lamp Examination Versus Anterior Segment Optical Coherence Tomography.Bioengineering (Basel, Switzerland) · 2026Article
- Novel advances in juvenile idiopathic arthritis associated uveitis.Arthritis research & therapy · 2026Review
- Correlation Between SUN Scale Grades and AS-OCT Cell Counts in Pediatric Uveitis: A Retrospective Central 7-Frame Analysis.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- AS-OCTA-Guided Versus Slit Lamp-Guided Laser Peripheral Iridotomy for Primary Angle-Closure Suspect Patients: A Short-Term Result.Translational vision science & technology · 2025Article
- Proposed Nomenclature for Landmarks in Anterior-Segment OCT: The APOSTEL-AS Panel Consensus.JAMA ophthalmology · 2025Article
- Reducing the risk of visual disability for children with juvenile idiopathic arthritis uveitis through disease surveillance: past and future challenges.Pediatric rheumatology online journal · 2025Review
- Automated quantification of anterior chamber cells using swept-source anterior segment optical coherence tomography.Journal of ophthalmic inflammation and infection · 2025Article
- Article
- The management of adult and paediatric uveitis for rheumatologists.Nature reviews. Rheumatology · 2024Review
- Overview on automated OCT assessment of anterior chamber cells in uveitis.International ophthalmology · 2024Article
- Diagnosis and Treatment of Uveitis in Children: A Summary of the Latest Data from a 5-Year Literature Review (2018-2023).Journal of clinical medicine · 2024Review
- Establishing the Normative Data Set Necessary for Imaging-Based Childhood Uveitis Surveillance: A Cross-Sectional Study.Investigative ophthalmology & visual science · 2024Observational
- Laser Flare Photometry to Monitor Childhood Chronic Uveitis: A Preliminary Report of a Monocentric Italian Experience.Diagnostics (Basel, Switzerland) · 2023Article
- Automated Quantitative Analysis of Anterior Segment Inflammation Using Swept-Source Anterior Segment Optical Coherence Tomography: A Pilot Study.Diagnostics (Basel, Switzerland) · 2022Article
- Anterior segment optical coherence tomography in uveitis: A comprehensive review of clinical applications, diagnostic insights, and future directions.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo evaluate the feasibility of anterior segment optical coherence tomography (AS-OCT) for measuring anterior chamber (AC) cells in children with uveitis and to compare different AS-OCT acquisition modes.
designValidity and reliability analysis.
methodsWe enrolled children younger than 18 years who had uveitis involving the anterior segment and children without eye disease as controls. All underwent clinical grading of AC cells. AC images of each eye were obtained using the Optovue Avanti RTVue XR AS-OCT. Two acquisition modes were used: a single cross-sectional line scan and an 8-line radial scan in an asterisk pattern. Two independent, masked graders counted cells manually on AS-OCT images. Rater agreement was assessed using intraclass correlation (ICC).
resultsIncluded were 30 children (59 eyes) with uveitis (median age 13.0 years, range 3-17 years) and 20 control children (40 eyes, median age 10.5 years, range 4-17 years). The number of eyes assigned each clinical grade of cells were as follows: none, 32 (54%); 0.5+, 12 (20.3%); 1+, 5 (8.5%); 2+, 8 (13.6%); 3+, 2 (3.4%). ICC of graders for line and radial scan protocols were 0.87 and 0.90. There was no significant difference between acquisition modes for pooled grader results (95% CI for difference: -0.04 to 0.14). ICC of cell counts between line and radial scan protocols was 0.85 (95% CI: 0.69-0.90). No control eyes had cells on AS-OCT images.
conclusionsQuantification of AC cell in children with uveitis is feasible with AS-OCT and has excellent reliability between different graders and acquisition modes.
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Registered trials
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